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Molecular Cancer Research
Molecular Cancer Research
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About the Cover

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Prevention of mortality stemming from the formation of metastatic lesions is a key goal of medical oncology, but few models exist that allow for effective screening of novel compounds that target the dissemination of cancer cells. The cover depicts a novel transgenic zebrafish model intended to address this shortcoming: by crossing tamoxifen-inducible Twist1a-ERT2 transgenic zebrafish with a second line overexpressing a homolog of activated EGFR, Nakayama and colleagues tracked the rate of hepatocellular carcinoma metastasis through the abdomen and tail (green, vasculature; red, metastases). Using this platform, the authors identified hydroxysteroid 11-β dehydrogenase 1 (HSD11β1) as a key regulator of initial metastatic dissemination and proposed pharmacologic means of inhibiting the process. For more information, see the Highlight on page 341 and the article on page 477.

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Molecular Cancer Research: 18 (3)
March 2020
Volume 18, Issue 3
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Issue Highlights

  • PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression
  • The YAP1 Signaling Inhibitors, Verteporfin and CA3, Suppress the Mesothelioma Cancer Stem Cell Phenotype
  • A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial–Mesenchymal Transition and Metastatic Dissemination
  • A PSCA/PGRN–NF-κB–Integrin–α4 Axis Promotes Prostate Cancer Cell Adhesion to Bone Marrow Endothelium and Enhances Metastatic Potential
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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