β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1

Sazzad Hassan; Ashok Pullikuth; Kyle C. Nelson; Anabel Flores; Yelena Karpova; Daniele Baiz; Sinan Zhu; Guangchao Sui; Yue Huang; Young A. Choi; Ralph D'Agostino; Ashok Hemal; Urs von Holzen; Waldemar Debinski; George Kulik

doi:10.1158/1541-7786.MCR-19-1037

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β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1

Sazzad Hassan, Ashok Pullikuth, Kyle C. Nelson, Anabel Flores, Yelena Karpova, Daniele Baiz, Sinan Zhu, Guangchao Sui, Yue Huang, Young A. Choi, Ralph D'Agostino Jr, Ashok Hemal, Urs von Holzen, Waldemar Debinski and George Kulik

Sazzad Hassan

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

2Indiana University School of Medicine-South Bend, South Bend, Indiana.

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Ashok Pullikuth

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Kyle C. Nelson

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Anabel Flores

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Yelena Karpova

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Daniele Baiz

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Sinan Zhu

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Guangchao Sui

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Yue Huang

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Young A. Choi

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Ralph D'Agostino Jr

3Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Ashok Hemal

4Department of Urology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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Urs von Holzen

2Indiana University School of Medicine-South Bend, South Bend, Indiana.

5Goshen Center for Cancer Care, Goshen, Indiana.

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Waldemar Debinski

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

3Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

6Brain Tumor Center of Excellence, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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George Kulik

1Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

3Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, North Carolina.

4Department of Urology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

7Department of Life Sciences, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.

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For correspondence: gkulik@wakehealth.edu

DOI: 10.1158/1541-7786.MCR-19-1037 Published December 2020

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December 2020
Volume 18, Issue 12

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β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1

Mol Cancer Res December 1 2020 (18) (12) 1839-1848; DOI: 10.1158/1541-7786.MCR-19-1037

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β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1

Mol Cancer Res December 1 2020 (18) (12) 1839-1848; DOI: 10.1158/1541-7786.MCR-19-1037

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