The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells

Erika Parasido; George S. Avetian; Aisha Naeem; Garrett Graham; Michael Pishvaian; Eric Glasgow; Shaila Mudambi; Yichien Lee; Chukwuemeka Ihemelandu; Muhammad Choudhry; Ivana Peran; Partha P. Banerjee; Maria Laura Avantaggiati; Kirsten Bryant; Elisa Baldelli; Mariaelena Pierobon; Lance Liotta; Emanuel Petricoin; Stanley T. Fricke; Aimy Sebastian; Joseph Cozzitorto; Gabriela G. Loots; Deepak Kumar; Stephen Byers; Eric Londin; Analisa DiFeo; Goutham Narla; Jordan Winter; Jonathan R. Brody; Olga Rodriguez; Chris Albanese

doi:10.1158/1541-7786.MCR-19-0191

Cancer Genes and Networks

The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells

Erika Parasido, George S. Avetian, Aisha Naeem, Garrett Graham, Michael Pishvaian, Eric Glasgow, Shaila Mudambi, Yichien Lee, Chukwuemeka Ihemelandu, Muhammad Choudhry, Ivana Peran, Partha P. Banerjee, Maria Laura Avantaggiati, Kirsten Bryant, Elisa Baldelli, Mariaelena Pierobon, Lance Liotta, Emanuel Petricoin, Stanley T. Fricke, Aimy Sebastian, Joseph Cozzitorto, Gabriela G. Loots, Deepak Kumar, Stephen Byers, Eric Londin, Analisa DiFeo, Goutham Narla, Jordan Winter, Jonathan R. Brody, Olga Rodriguez and Chris Albanese

Erika Parasido

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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George S. Avetian

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Aisha Naeem

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Garrett Graham

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Michael Pishvaian

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Eric Glasgow

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Shaila Mudambi

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Yichien Lee

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Chukwuemeka Ihemelandu

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Muhammad Choudhry

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Ivana Peran

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Partha P. Banerjee

Department of Biochemistry, Molecular and Cell Biology, Georgetown University Medical Center, Washington, D.C.

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Maria Laura Avantaggiati

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Kirsten Bryant

Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina.

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Elisa Baldelli

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.

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Mariaelena Pierobon

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.

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Lance Liotta

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.

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Emanuel Petricoin

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.

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Stanley T. Fricke

Center for Translational Imaging, Georgetown University Medical Center, Washington, D.C.

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Aimy Sebastian

Biology and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California.

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Joseph Cozzitorto

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Gabriela G. Loots

Biology and Biotechnology Division, Lawrence Livermore National Laboratory, Livermore, California.

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Deepak Kumar

Department of Pharmaceutical Sciences, Julius L. Chambers Biomedical/Biotechnology Research Institute (JLC-BBRI), North Carolina Central University, Durham, North Carolina.

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Stephen Byers

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

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Eric Londin

Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Analisa DiFeo

Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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Goutham Narla

Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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Jordan Winter

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.Case Western Reserve School of Medicine, Case Comprehensive Cancer Center and University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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Jonathan R. Brody

Division of Surgical Research, Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Olga Rodriguez

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.Center for Translational Imaging, Georgetown University Medical Center, Washington, D.C.

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Chris Albanese

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For correspondence: albanese@georgetown.edu

DOI: 10.1158/1541-7786.MCR-19-0191 Published September 2019

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September 2019
Volume 17, Issue 9

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The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells