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Molecular Cancer Research
Molecular Cancer Research
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About the Cover

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ABOUT THE COVER
The cover image depicts confocal light microscopy of tumor-bearing mouse foot pad tissue. Myelinated epidermal nerve fibers have been labeled with S-100 antibody (red). FITC-Phalloidin reveals actin structure in the skin (green), whereas Hoechst indicates cell nuclei (blue). Cisplatin therapy is associated with reduced numbers of large myelinated epidermal nerve fibers in the skin, leading to loss of sensation. Here, Zhu and colleagues demonstrate that the Rho kinase (ROCK) inhibitor Y-27632 protects myelinated epidermal nerve fibers from cisplatin-induced impairment in mouse foot pad tissue. See the Highlight on page 1775 and the article on page 1910 for more information.

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Molecular Cancer Research: 17 (9)
September 2019
Volume 17, Issue 9
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Issue Highlights

  • Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA–NF-κB
  • The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
  • Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations
  • Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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