T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis

Christophe Cataisson; Rosalba Salcedo; Aleksandra M. Michalowski; Mary Klosterman; Shruti Naik; Luowei Li; Michelle J. Pan; Amalia Sweet; Jin-Qiu Chen; Laurie G. Kostecka; Megan Karwan; Loretta Smith; Ren-Ming Dai; C. Andrew Stewart; Lyudmila Lyakh; Wang-Ting Hsieh; Asra Khan; Howard Yang; Maxwell Lee; Giorgio Trinchieri; Stuart H. Yuspa

doi:10.1158/1541-7786.MCR-19-0227

Tumor Microenvironment and Immunobiology

T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis

Christophe Cataisson, Rosalba Salcedo, Aleksandra M. Michalowski, Mary Klosterman, Shruti Naik, Luowei Li, Michelle J. Pan, Amalia Sweet, Jin-Qiu Chen, Laurie G. Kostecka, Megan Karwan, Loretta Smith, Ren-Ming Dai, C. Andrew Stewart, Lyudmila Lyakh, Wang-Ting Hsieh, Asra Khan, Howard Yang, Maxwell Lee, Giorgio Trinchieri and Stuart H. Yuspa

Christophe Cataisson

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Rosalba Salcedo

2Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.

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Aleksandra M. Michalowski

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Mary Klosterman

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Shruti Naik

3Department of Pathology and Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, New York.

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Luowei Li

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Michelle J. Pan

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Amalia Sweet

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Jin-Qiu Chen

4Collaborative Protein Technology Resource, Center for Cancer Research, NCI, Bethesda, Maryland.

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Laurie G. Kostecka

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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ORCID record for Laurie G. Kostecka

Megan Karwan

5Leidos Biomedical Research, Inc., Frederick, Maryland.

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Loretta Smith

2Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.

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Ren-Ming Dai

5Leidos Biomedical Research, Inc., Frederick, Maryland.

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C. Andrew Stewart

2Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.

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ORCID record for C. Andrew Stewart

Lyudmila Lyakh

2Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.

6Division of Allergy, Immunology & Transplantation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda Maryland.

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Wang-Ting Hsieh

5Leidos Biomedical Research, Inc., Frederick, Maryland.

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Asra Khan

2Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.

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Howard Yang

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Maxwell Lee

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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Giorgio Trinchieri

2Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.

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For correspondence: yuspas@mail.nih.gov trinchig@mail.nih.gov

Stuart H. Yuspa

1Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.

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For correspondence: yuspas@mail.nih.gov trinchig@mail.nih.gov

DOI: 10.1158/1541-7786.MCR-19-0227 Published August 2019

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August 2019
Volume 17, Issue 8

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T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis