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Molecular Cancer Research
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Signal Transduction and Functional Imaging

E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Mohit Kumar Jolly, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, R. Garland Austin, Daniella Runyambo, Alexander J. Hish, Suzanne Bartholf DeWitt, Jason T. George, R. Timothy Kreulen, Mary-Keara Boss, Alexander L. Lazarides, David L. Kerr, Drew G. Gerber, Dharshan Sivaraj, Andrew J. Armstrong, Mark W. Dewhirst, William C. Eward, Herbert Levine and Jason A. Somarelli
Mohit Kumar Jolly
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
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Kathryn E. Ware
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Shengnan Xu
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Shivee Gilja
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Samantha Shetler
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Yanjun Yang
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
3Department of Applied Physics, Rice University, Houston, Texas.
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Xueyang Wang
4School of Medicine, Johns Hopkins University, Baltimore, Maryland.
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R. Garland Austin
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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  • ORCID record for R. Garland Austin
Daniella Runyambo
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Alexander J. Hish
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Suzanne Bartholf DeWitt
5Department of Pathology, Duke University Medical Center, Durham, North Carolina.
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Jason T. George
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
6Department of Bioengineering, Rice University, Houston, Texas.
7Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas.
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R. Timothy Kreulen
8Department of Orthopedics, Duke University Medical Center, Durham, North Carolina.
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Mary-Keara Boss
9Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado.
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Alexander L. Lazarides
8Department of Orthopedics, Duke University Medical Center, Durham, North Carolina.
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David L. Kerr
8Department of Orthopedics, Duke University Medical Center, Durham, North Carolina.
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Drew G. Gerber
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Dharshan Sivaraj
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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Andrew J. Armstrong
10Solid Tumor Program, Duke University Medical Center, Durham, North Carolina.
11Duke Prostate Center, Duke University Medical Center, Durham, North Carolina.
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Mark W. Dewhirst
12Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
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William C. Eward
8Department of Orthopedics, Duke University Medical Center, Durham, North Carolina.
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Herbert Levine
1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
6Department of Bioengineering, Rice University, Houston, Texas.
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Jason A. Somarelli
2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
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  • For correspondence: jason.somarelli@duke.edu
DOI: 10.1158/1541-7786.MCR-18-0763 Published June 2019
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Article Information

Volume 17, Issue 6, pp. 1391-1402

DOI 
https://doi.org/10.1158/1541-7786.MCR-18-0763
PubMed 
30862685

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received July 19, 2018
  • Revision received November 16, 2018
  • Accepted March 8, 2019
  • Published first March 12, 2019.

Article Versions

  • Previous version (March 12, 2019 - 06:59).
  • Previous version (April 17, 2019 - 06:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Mohit Kumar Jolly*,1,
  2. Kathryn E. Ware*,2,
  3. Shengnan Xu2,
  4. Shivee Gilja2,
  5. Samantha Shetler2,
  6. Yanjun Yang1,3,
  7. Xueyang Wang4,
  8. R. Garland Austin2,
  9. Daniella Runyambo2,
  10. Alexander J. Hish2,
  11. Suzanne Bartholf DeWitt5,
  12. Jason T. George1,6,7,
  13. R. Timothy Kreulen8,
  14. Mary-Keara Boss9,
  15. Alexander L. Lazarides8,
  16. David L. Kerr8,
  17. Drew G. Gerber2,
  18. Dharshan Sivaraj2,
  19. Andrew J. Armstrong10,11,
  20. Mark W. Dewhirst12,
  21. William C. Eward8,
  22. Herbert Levine1,6, and
  23. Jason A. Somarelli2,*
  1. 1Center for Theoretical Biological Physics, Rice University, Houston, Texas.
  2. 2Department of Medicine, Duke University Medical Center, Durham, North Carolina.
  3. 3Department of Applied Physics, Rice University, Houston, Texas.
  4. 4School of Medicine, Johns Hopkins University, Baltimore, Maryland.
  5. 5Department of Pathology, Duke University Medical Center, Durham, North Carolina.
  6. 6Department of Bioengineering, Rice University, Houston, Texas.
  7. 7Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas.
  8. 8Department of Orthopedics, Duke University Medical Center, Durham, North Carolina.
  9. 9Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado.
  10. 10Solid Tumor Program, Duke University Medical Center, Durham, North Carolina.
  11. 11Duke Prostate Center, Duke University Medical Center, Durham, North Carolina.
  12. 12Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
  1. ↵*Corresponding Author:
    Jason A. Somarelli, Duke University, 3044 GSRBI, 905 Lasalle Street, Durham, NC 27710. Phone: 919-681-9604; Fax: 919-681-9605; E-mail: jason.somarelli{at}duke.edu
  1. M.K. Jolly and K.E. Ware contributed equally to and are the co-first authors of this article.

  • Current address for M.K. Jolly: Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India.

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Molecular Cancer Research: 17 (6)
June 2019
Volume 17, Issue 6
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E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms
Mohit Kumar Jolly, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, R. Garland Austin, Daniella Runyambo, Alexander J. Hish, Suzanne Bartholf DeWitt, Jason T. George, R. Timothy Kreulen, Mary-Keara Boss, Alexander L. Lazarides, David L. Kerr, Drew G. Gerber, Dharshan Sivaraj, Andrew J. Armstrong, Mark W. Dewhirst, William C. Eward, Herbert Levine and Jason A. Somarelli
Mol Cancer Res June 1 2019 (17) (6) 1391-1402; DOI: 10.1158/1541-7786.MCR-18-0763

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E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms
Mohit Kumar Jolly, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, R. Garland Austin, Daniella Runyambo, Alexander J. Hish, Suzanne Bartholf DeWitt, Jason T. George, R. Timothy Kreulen, Mary-Keara Boss, Alexander L. Lazarides, David L. Kerr, Drew G. Gerber, Dharshan Sivaraj, Andrew J. Armstrong, Mark W. Dewhirst, William C. Eward, Herbert Levine and Jason A. Somarelli
Mol Cancer Res June 1 2019 (17) (6) 1391-1402; DOI: 10.1158/1541-7786.MCR-18-0763
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