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Molecular Cancer Research
Molecular Cancer Research
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About the Cover

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ABOUT THE COVER
Metabolic alterations underlie the acquisition of a host of protumorigenic and progression-associated phenotypes. The cover image depicts three-dimensional imaging of an irradiated MCF7 xenograft tumor in which OGA, an enzyme that catalyzes the removal of O-linked N-acetyl glucosamine, had been ablated using RNA interference (DNA damage foci, red; shRNA expression, green; vascular endothelium, cyan). Increased protein O-GlcNAcylation resulting from OGA loss was associated with faster resolution of DNA damage. Taken together, the data suggest that rewiring of the hexosamine biosynthetic pathway may drive resistance to radiotherapy.

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Molecular Cancer Research: 17 (6)
June 2019
Volume 17, Issue 6
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Issue Highlights

  • Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling
  • The Pioneering Role of GATA2 in Androgen Receptor Variant Regulation Is Controlled by Bromodomain and Extraterminal Proteins in Castrate-Resistant Prostate Cancer
  • O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors
  • Metabolic Detection of Bruton's Tyrosine Kinase Inhibition in Mantle Cell Lymphoma Cells
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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