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Molecular Cancer Research
Molecular Cancer Research

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About the Cover

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ABOUT THE COVER
In this issue (beginning on page 370), Mooneyham and colleagues demonstrate that UNC-45A is a novel microtubule-associated protein that antagonizes the effect of paclitaxel in ovarian cancer cells, leading to chemoresistance. The immunofluorescent cover image shows strong co-localization between UNC-45A (red) and alpha tubulin (green) in synchronized metaphase HeLa cells. This finding was key in the later identification of UNC-45A as a novel microtubule-associated protein that functions to destabilize microtubules and confer paclitaxel resistance. Together, this study reveals UNC-45A as a promising biomarker and molecular target for paclitaxel-resistant human cancers.
Cover image by Mooneyham not featured in article.

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Molecular Cancer Research: 17 (2)
February 2019
Volume 17, Issue 2
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Issue Highlights

  • Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas
  • Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy
  • Modulation of Mutant KrasG12D-Driven Lung Tumorigenesis In Vivo by Gain or Loss of PCDH7 Function
  • PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance
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Copyright © 2019 by the American Association for Cancer Research.

Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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