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Molecular Cancer Research
Molecular Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Res February 1 2019 17 (2) 335-335;

Review

  • Review
    Internalization of Exosomes through Receptor-Mediated Endocytosis
    Amber Gonda, Janviere Kabagwira, Girish N. Senthil and Nathan R. Wall
    Mol Cancer Res February 1 2019 17 (2) 337-347; DOI:10.1158/1541-7786.MCR-18-0891

Rapid Impact

  • Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer
    Rapid Impact
    Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer
    Yuqing Zhang, Amanda Kirane, Huocong Huang, Noah B. Sorrelle, Francis J. Burrows, Michael T. Dellinger and Rolf A. Brekken
    Mol Cancer Res February 1 2019 17 (2) 348-355; DOI:10.1158/1541-7786.MCR-18-0427

Cell Cycle and Senescence

  • Cell Cycle and Senescence | AuthorChoice
    AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer
    Haley D. Axelrod, Kenneth C. Valkenburg, Sarah R. Amend, Jessica L. Hicks, Princy Parsana, Gonzalo Torga, Angelo M. DeMarzo and Kenneth J. Pienta
    Mol Cancer Res February 1 2019 17 (2) 356-369; DOI:10.1158/1541-7786.MCR-18-0718

  • Cell Cycle and Senescence
    UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells
    Ashley Mooneyham, Yoshie Iizuka, Qing Yang, Courtney Coombes, Mark McClellan, Vijayalakshmi Shridhar, Edith Emmings, Mihir Shetty, Liqiang Chen, Teng Ai, Joyce Meints, Michael K. Lee, Melissa Gardner and Martina Bazzaro
    Mol Cancer Res February 1 2019 17 (2) 370-383; DOI:10.1158/1541-7786.MCR-18-0670

Cell Death and Survival

  • Cell Death and Survival
    Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells
    Laure Malric, Sylvie Monferran, Caroline Delmas, Florent Arnauduc, Perrine Dahan, Sabrina Boyrie, Pauline Deshors, Vincent Lubrano, Dina Ferreira Da Mota, Julia Gilhodes, Thomas Filleron, Aurore Siegfried, Solène Evrard, Aline Kowalski-Chauvel, Elizabeth Cohen-Jonathan Moyal, Christine Toulas and Anthony Lemarié
    Mol Cancer Res February 1 2019 17 (2) 384-397; DOI:10.1158/1541-7786.MCR-18-0386

  • Cell Death and Survival | AuthorChoice
    αvβ3 Integrin Mediates Radioresistance of Prostate Cancer Cells through Regulation of Survivin
    Tao Wang, Jiayi Huang, Mai Vue, Michael R. Alavian, Hira Lal Goel, Dario C. Altieri, Lucia R. Languino and Thomas J. FitzGerald
    Mol Cancer Res February 1 2019 17 (2) 398-408; DOI:10.1158/1541-7786.MCR-18-0544

  • Cell Death and Survival | AuthorChoice
    PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow
    Todd A. Hopkins, William B. Ainsworth, Paul A. Ellis, Cherrie K. Donawho, Enrico L. DiGiammarino, Sanjay C. Panchal, Vivek C. Abraham, Mikkel A. Algire, Yan Shi, Amanda M. Olson, Eric F. Johnson, Julie L. Wilsbacher and David Maag
    Mol Cancer Res February 1 2019 17 (2) 409-419; DOI:10.1158/1541-7786.MCR-18-0138

  • Cell Death and Survival
    Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy
    Wei Xiao, Mohammed L. Ibrahim, Priscilla S. Redd, John D. Klement, Chunwan Lu, Dafeng Yang, Natasha M. Savage and Kebin Liu
    Mol Cancer Res February 1 2019 17 (2) 420-430; DOI:10.1158/1541-7786.MCR-18-0455

DNA Damage and Repair

  • PARP Inhibition Induces Enrichment of DNA Repair–Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells
    DNA Damage and Repair | AuthorChoice
    PARP Inhibition Induces Enrichment of DNA Repair–Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells
    Chiara Bellio, Celeste DiGloria, Rosemary Foster, Kaitlyn James, Panagiotis A. Konstantinopoulos, Whitfield B. Growdon and Bo R. Rueda
    Mol Cancer Res February 1 2019 17 (2) 431-445; DOI:10.1158/1541-7786.MCR-18-0594

Genomics

  • Genomics | AuthorChoice
    Genetic and Epigenetic Determinants of Aggressiveness in Cribriform Carcinoma of the Prostate
    Habiba Elfandy, Joshua Armenia, Filippo Pederzoli, Eli Pullman, Nelma Pertega-Gomes, Nikolaus Schultz, Kartik Viswanathan, Aram Vosoughi, Mirjam Blattner, Konrad H. Stopsack, Giorgia Zadra, Kathryn L. Penney, Juan Miguel Mosquera, Svitlana Tyekucheva, Lorelei A. Mucci, Christopher Barbieri and Massimo Loda
    Mol Cancer Res February 1 2019 17 (2) 446-456; DOI:10.1158/1541-7786.MCR-18-0440

  • Genomics
    Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer
    Ahmed Basudan, Nolan Priedigkeit, Ryan J. Hartmaier, Ethan S. Sokol, Amir Bahreini, Rebecca J. Watters, Michelle M. Boisen, Rohit Bhargava, Kurt R. Weiss, Maria M. Karsten, Carsten Denkert, Jens-Uwe Blohmer, Jose P. Leone, Ronald L. Hamilton, Adam M. Brufsky, Esther Elishaev, Peter C. Lucas, Adrian V. Lee and Steffi Oesterreich
    Mol Cancer Res February 1 2019 17 (2) 457-468; DOI:10.1158/1541-7786.MCR-18-0946

  • Genomics
    High Prevalence of a Hotspot of Noncoding Somatic Mutations in Intron 6 of GPR126 in Bladder Cancer
    Simon Garinet, Géraldine Pignot, Sophie Vacher, Constance Le Goux, Anne Schnitzler, Walid Chemlali, Nanor Sirab, Nicolas Barry Delongchamps, Marc Zerbib, Mathilde Sibony, Yves Allory, Diane Damotte and Ivan Bieche
    Mol Cancer Res February 1 2019 17 (2) 469-475; DOI:10.1158/1541-7786.MCR-18-0363

  • Genomics
    Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas
    Fengju Chen, Yiqun Zhang, Sooryanarayana Varambally and Chad J. Creighton
    Mol Cancer Res February 1 2019 17 (2) 476-487; DOI:10.1158/1541-7786.MCR-18-0601

  • Genomics
    Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer
    Kathryn T. Baker, Daniela Nachmanson, Shilpa Kumar, Mary J. Emond, Cigdem Ussakli, Teresa A. Brentnall, Scott R. Kennedy and Rosa Ana Risques
    Mol Cancer Res February 1 2019 17 (2) 488-498; DOI:10.1158/1541-7786.MCR-18-0520

  • Genomics
    Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non–Small Cell Lung Cancer Cells
    Kei Namba, Kazuhiko Shien, Yuta Takahashi, Hidejiro Torigoe, Hiroki Sato, Takahiro Yoshioka, Tatsuaki Takeda, Eisuke Kurihara, Yusuke Ogoshi, Hiromasa Yamamoto, Junichi Soh, Shuta Tomida and Shinichi Toyooka
    Mol Cancer Res February 1 2019 17 (2) 499-507; DOI:10.1158/1541-7786.MCR-18-0628

Oncogenes and Tumor Suppressors

  • Oncogenes and Tumor Suppressors
    RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer
    Mahsa Zarei, Shruti Lal, Ali Vaziri-Gohar, Kevin O'Hayer, Venugopal Gunda, Pankaj K. Singh, Jonathan R. Brody and Jordan M. Winter
    Mol Cancer Res February 1 2019 17 (2) 508-520; DOI:10.1158/1541-7786.MCR-18-0557

  • Oncogenes and Tumor Suppressors
    Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling
    Wenhui Wang, Shan Li, Pengyu Liu, Kostandinos Sideras, Harmen J.G. van de Werken, Marieke van der Heide, Wanlu Cao, Marla Lavrijsen, Maikel P. Peppelenbosch, Marco Bruno, Qiuwei Pan and Ron Smits
    Mol Cancer Res February 1 2019 17 (2) 521-531; DOI:10.1158/1541-7786.MCR-18-0054

  • Oncogenes and Tumor Suppressors
    The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT
    Molly R. Ryan, Christal D. Sohl, BeiBei Luo and Karen S. Anderson
    Mol Cancer Res February 1 2019 17 (2) 532-543; DOI:10.1158/1541-7786.MCR-18-0429

  • Oncogenes and Tumor Suppressors
    c-MYC Drives Breast Cancer Metastasis to the Brain, but Promotes Synthetic Lethality with TRAIL
    Ho Yeon Lee, Junghwa Cha, Seon Kyu Kim, Jun Hyung Park, Ki Hoon Song, Pilnam Kim and Mi-Young Kim
    Mol Cancer Res February 1 2019 17 (2) 544-554; DOI:10.1158/1541-7786.MCR-18-0630

  • Oncogenes and Tumor Suppressors
    DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss
    Chieh-Hsiang Chan, Chun-Ming Chen, Yan-Hwa Wu Lee and Li-Ru You
    Mol Cancer Res February 1 2019 17 (2) 555-566; DOI:10.1158/1541-7786.MCR-18-0551

  • Oncogenes and Tumor Suppressors
    Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma
    Eric P. Rahrmann, Natalie K. Wolf, George M. Otto, Lynn Heltemes-Harris, Laura B. Ramsey, Jingmin Shu, Rebecca S. LaRue, Michael A. Linden, Susan K. Rathe, Timothy K. Starr, Michael A. Farrar, Branden S. Moriarity and David A. Largaespada
    Mol Cancer Res February 1 2019 17 (2) 567-582; DOI:10.1158/1541-7786.MCR-18-0582

  • Oncogenes and Tumor Suppressors
    PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas
    Kristen S. Hill, Evan R. Roberts, Xue Wang, Ellen Marin, Taeeun D. Park, Sorany Son, Yuan Ren, Bin Fang, Sean Yoder, Sungjune Kim, Lixin Wan, Amod A. Sarnaik, John M. Koomen, Jane L. Messina, Jamie K. Teer, Youngchul Kim, Jie Wu, Charles E. Chalfant and Minjung Kim
    Mol Cancer Res February 1 2019 17 (2) 583-593; DOI:10.1158/1541-7786.MCR-18-0777

  • Oncogenes and Tumor Suppressors | AuthorChoice
    Modulation of Mutant KrasG12D-Driven Lung Tumorigenesis In Vivo by Gain or Loss of PCDH7 Function
    Xiaorong Zhou, Mahesh S. Padanad, Bret M. Evers, Bethany Smith, Nicole Novaresi, Shruthy Suresh, James A. Richardson, Emily Stein, Jingfei Zhu, Robert E. Hammer and Kathryn A. O'Donnell
    Mol Cancer Res February 1 2019 17 (2) 594-603; DOI:10.1158/1541-7786.MCR-18-0739

  • Oncogenes and Tumor Suppressors
    CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells through SRC and PKC Activation
    Min Yao, Wei Fang, Curtis Smart, Qingting Hu, Shixia Huang, Nehemiah Alvarez, Patrick Fields and Nikki Cheng
    Mol Cancer Res February 1 2019 17 (2) 604-617; DOI:10.1158/1541-7786.MCR-18-0750

  • Oncogenes and Tumor Suppressors
    PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance
    Kenji Zennami, Su Mi Choi, Ross Liao, Ying Li, Wikum Dinalankara, Luigi Marchionni, Fatema H. Rafiqi, Akira Kurozumi, Koji Hatano and Shawn E. Lupold
    Mol Cancer Res February 1 2019 17 (2) 618-627; DOI:10.1158/1541-7786.MCR-18-0837

Signal Transduction

  • Signal Transduction | AuthorChoice
    Epigenetic Silencing of THY1 Tracks the Acquisition of the Notch1–EGFR Signaling in a Xenograft Model of CD44+/CD24low/CD90+ Myoepithelial Cells
    Micaela Montanari, Maria Rita Carbone, Luigi Coppola, Mario Giuliano, Grazia Arpino, Rossella Lauria, Agostina Nardone, Felicia Leccia, Meghana V. Trivedi, Corrado Garbi, Roberto Bianco, Enrico V. Avvedimento, Sabino De Placido and Bianca Maria Veneziani
    Mol Cancer Res February 1 2019 17 (2) 628-641; DOI:10.1158/1541-7786.MCR-17-0324

  • Signal Transduction
    Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance
    Ida Aronchik, Yumin Dai, Matt Labenski, Carmen Barnes, Terri Jones, Lixin Qiao, Lisa Beebe, Mehnaz Malek, Winfried Elis, Tao Shi, Konstantinos Mavrommatis, Gordon L. Bray and Ellen H. Filvaroff
    Mol Cancer Res February 1 2019 17 (2) 642-654; DOI:10.1158/1541-7786.MCR-17-0554

  • Signal Transduction
    Nuclear E-Cadherin Acetylation Promotes Colorectal Tumorigenesis via Enhancing β-Catenin Activity
    Yongxu Zhao, Tao Yu, Nan Zhang, Jianxia Chen, Peng Zhang, Shuang Li, Lijun Luo, Zhenling Cui, Yue Qin and Feng Liu
    Mol Cancer Res February 1 2019 17 (2) 655-665; DOI:10.1158/1541-7786.MCR-18-0637

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Molecular Cancer Research: 17 (2)
February 2019
Volume 17, Issue 2
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

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Issue Highlights

  • Molecular Correlates of Metastasis by Systematic Pan-Cancer Analysis Across The Cancer Genome Atlas
  • Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy
  • Modulation of Mutant KrasG12D-Driven Lung Tumorigenesis In Vivo by Gain or Loss of PCDH7 Function
  • PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance

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  • Review
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  • Cell Cycle and Senescence
  • Cell Death and Survival
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  • Signal Transduction
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  • 27HC Disrupts Lipid Raft IL6–JAK–STAT3 in Prostate Cancer
  • Mesenchymal/MAPK Signatures of TERT Promoter Mutants
  • Evolving Evolvability and the Origins of Lethal Cancer
  • Vincristine Depletes Microtubule-Bound MYC in Mitosis
  • Combinatorial Lethality of OGT and CDK9 Inhibitors
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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