De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer

Naser Jafari; James Drury; Andrew J. Morris; Fredrick O. Onono; Payton D. Stevens; Tianyan Gao; Jinpeng Liu; Chi Wang; Eun Y. Lee; Heidi L. Weiss; B. Mark Evers; Yekaterina Y. Zaytseva

doi:10.1158/1541-7786.MCR-18-0199

Metabolism

De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer

Naser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers and Yekaterina Y. Zaytseva

Naser Jafari

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky.Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

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James Drury

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky.

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Andrew J. Morris

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.Division of Cardiovascular Medicine and The Gill Heart and Vascular Institute, University of Kentucky, Lexington, Kentucky.

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Fredrick O. Onono

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.Division of Cardiovascular Medicine and The Gill Heart and Vascular Institute, University of Kentucky, Lexington, Kentucky.

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Payton D. Stevens

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky.

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Tianyan Gao

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky.

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Jinpeng Liu

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

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Chi Wang

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

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Eun Y. Lee

Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky.

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Heidi L. Weiss

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

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B. Mark Evers

Markey Cancer Center, University of Kentucky, Lexington, Kentucky.Department of Surgery, University of Kentucky, Lexington, Kentucky.

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Yekaterina Y. Zaytseva

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky.Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

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For correspondence: yyzayt2@uky.edu

DOI: 10.1158/1541-7786.MCR-18-0199 Published January 2019

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January 2019
Volume 17, Issue 1

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De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer

Naser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers and Yekaterina Y. Zaytseva

Mol Cancer Res January 1 2019 (17) (1) 140-152; DOI: 10.1158/1541-7786.MCR-18-0199

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De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer

Naser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers and Yekaterina Y. Zaytseva

Mol Cancer Res January 1 2019 (17) (1) 140-152; DOI: 10.1158/1541-7786.MCR-18-0199

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