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Molecular Cancer Research
Molecular Cancer Research

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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Res January 1 2019 17 (1) 1-1;

Perspective

  • Perspective
    Lung-Enriched Mutations in the p53 Tumor Suppressor: A Paradigm for Tissue-Specific Gain of Oncogenic Function
    Julie A. Barta and Steven B. McMahon
    Mol Cancer Res January 1 2019 17 (1) 3-9; DOI:10.1158/1541-7786.MCR-18-0357

Cell Cycle and Senescence

  • Cell Cycle and Senescence
    Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression
    Feifei Wang, Ling Wang, Laura A. Fisher, Chunling Li, Weidong Wang and Aimin Peng
    Mol Cancer Res January 1 2019 17 (1) 10-19; DOI:10.1158/1541-7786.MCR-17-0670

Cell Death and Survival

  • Cell Death and Survival
    Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion
    Rui Wang, Rajat Bhattacharya, Xiangcang Ye, Fan Fan, Delphine R. Boulbes and Lee M. Ellis
    Mol Cancer Res January 1 2019 17 (1) 20-29; DOI:10.1158/1541-7786.MCR-18-0341

Chromatin, Epigenetics, and RNA Regulation

  • Chromatin, Epigenetics, and RNA Regulation
    Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression
    Thomas J. Rogers, Jessica L. Christenson, Lisa I. Greene, Kathleen I. O'Neill, Michelle M. Williams, Michael A. Gordon, Travis Nemkov, Angelo D'Alessandro, Greg D. Degala, Jimin Shin, Aik-Choon Tan, Diana M. Cittelly, James R. Lambert and Jennifer K. Richer
    Mol Cancer Res January 1 2019 17 (1) 30-41; DOI:10.1158/1541-7786.MCR-18-0246

DNA Damage and Repair

  • DNA Damage and Repair
    Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition
    Abid R. Mattoo, Alex Joun and J. Milburn Jessup
    Mol Cancer Res January 1 2019 17 (1) 42-53; DOI:10.1158/1541-7786.MCR-18-0650

  • DNA Damage and Repair
    Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk
    Ambre Petitalot, Elodie Dardillac, Eric Jacquet, Naima Nhiri, Josée Guirouilh-Barbat, Patrick Julien, Isslam Bouazzaoui, Dorine Bonte, Jean Feunteun, Jeff A. Schnell, Philippe Lafitte, Jean-Christophe Aude, Catherine Noguès, Etienne Rouleau, Rosette Lidereau, Bernard S. Lopez, Sophie Zinn-Justin and Sandrine M. Caputo; on behalf of the UNICANCER Genetic Group BRCA network
    Mol Cancer Res January 1 2019 17 (1) 54-69; DOI:10.1158/1541-7786.MCR-17-0357

Genomics

  • Genomics | AuthorChoice
    Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors
    Isabel Romero-Calvo, Christopher R. Weber, Mohana Ray, Miguel Brown, Kori Kirby, Rajib K. Nandi, Tiha M. Long, Samantha M. Sparrow, Andrey Ugolkov, Wenan Qiang, Yilin Zhang, Tonya Brunetti, Hedy Kindler, Jeremy P. Segal, Andrey Rzhetsky, Andrew P. Mazar, Mary M. Buschmann, Ralph Weichselbaum, Kevin Roggin and Kevin P. White
    Mol Cancer Res January 1 2019 17 (1) 70-83; DOI:10.1158/1541-7786.MCR-18-0531

  • Genomics
    Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis
    Hye-Young Nam, Darshan S. Chandrashekar, Anirban Kundu, Sandeep Shelar, Eun-Young Kho, Guru Sonpavde, Gurudatta Naik, Pooja Ghatalia, Carolina B. Livi, Sooryanarayana Varambally and Sunil Sudarshan
    Mol Cancer Res January 1 2019 17 (1) 84-96; DOI:10.1158/1541-7786.MCR-17-0636

  • Genomics
    Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers
    Timothy R. Wilson, Akshata R. Udyavar, Ching-Wei Chang, Jill M. Spoerke, Junko Aimi, Heidi M. Savage, Anneleen Daemen, Joyce A. O'Shaughnessy, Richard Bourgon and Mark R. Lackner
    Mol Cancer Res January 1 2019 17 (1) 97-108; DOI:10.1158/1541-7786.MCR-18-0619

  • Genomics
    A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis
    Yanding Zhao, Evelien Schaafsma, Ivan P. Gorlov, Eva Hernando, Nancy E. Thomas, Ronglai Shen, Mary Jo Turk, Marianne Berwick, Christopher I. Amos and Chao Cheng
    Mol Cancer Res January 1 2019 17 (1) 109-119; DOI:10.1158/1541-7786.MCR-18-0173

  • Genomics
    Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining
    D. Vicky de Boer, Arjen Brink, Marijke Buijze, Marijke Stigter-van Walsum, Keith D. Hunter, Bauke Ylstra, Elisabeth Bloemena, C. René Leemans and Ruud H. Brakenhoff
    Mol Cancer Res January 1 2019 17 (1) 120-130; DOI:10.1158/1541-7786.MCR-18-0445

Metabolism

  • Metabolism
    A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma
    Lisa I. Greene, Tullia C. Bruno, Jessica L. Christenson, Angelo D'Alessandro, Rachel Culp-Hill, Kathleen Torkko, Virginia F. Borges, Jill E. Slansky and Jennifer K. Richer
    Mol Cancer Res January 1 2019 17 (1) 131-139; DOI:10.1158/1541-7786.MCR-18-0362

  • Metabolism
    De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer
    Naser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers and Yekaterina Y. Zaytseva
    Mol Cancer Res January 1 2019 17 (1) 140-152; DOI:10.1158/1541-7786.MCR-18-0199

Oncogenes and Tumor Suppressors

  • Oncogenes and Tumor Suppressors
    p53–Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT
    Yang Yang-Hartwich, Roslyn Tedja, Cai M. Roberts, Jamie Goodner-Bingham, Carlos Cardenas, Marta Gurea, Natalia J. Sumi, Ayesha B. Alvero, Carlotta A. Glackin and Gil Mor
    Mol Cancer Res January 1 2019 17 (1) 153-164; DOI:10.1158/1541-7786.MCR-18-0238

  • Oncogenes and Tumor Suppressors
    Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium–specific Deletion of Klf4
    Vincent W. Yang, Yang Liu, Julie Kim, Kenneth R. Shroyer and Agnieszka B. Bialkowska
    Mol Cancer Res January 1 2019 17 (1) 165-176; DOI:10.1158/1541-7786.MCR-18-0399

  • Oncogenes and Tumor Suppressors
    Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing
    Maria Alexiadis, Simone M. Rowley, Simon Chu, Dilys T.H. Leung, Colin J.R. Stewart, Kaushalya C. Amarasinghe, Ian G. Campbell and Peter J. Fuller
    Mol Cancer Res January 1 2019 17 (1) 177-185; DOI:10.1158/1541-7786.MCR-18-0359

  • Oncogenes and Tumor Suppressors
    p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma
    Yun Wei, Victor Maximov, Sorana A. Morrissy, Michael D. Taylor, David C. Pallas and Anna Marie Kenney
    Mol Cancer Res January 1 2019 17 (1) 186-198; DOI:10.1158/1541-7786.MCR-18-0485

  • Oncogenes and Tumor Suppressors
    Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma
    Grace P. Leung, Tianshu Feng, Frederic D. Sigoillot, Felipe C. Geyer, Matthew D. Shirley, David A. Ruddy, Daniel P. Rakiec, Alyson K. Freeman, Jeffrey A. Engelman, Mariela Jaskelioff and Darrin D. Stuart
    Mol Cancer Res January 1 2019 17 (1) 199-211; DOI:10.1158/1541-7786.MCR-18-0327

Signal Transduction

  • Signal Transduction
    Alectinib Resistance in ALK-Rearranged Lung Cancer by Dual Salvage Signaling in a Clinically Paired Resistance Model
    Takahiro Tsuji, Hiroaki Ozasa, Wataru Aoki, Shunsuke Aburaya, Tomoko Funazo, Koh Furugaki, Yasushi Yoshimura, Hitomi Ajimizu, Ryoko Okutani, Yuto Yasuda, Takashi Nomizo, Kiyoshi Uemasu, Koichi Hasegawa, Hironori Yoshida, Yoshitaka Yagi, Hiroki Nagai, Yuichi Sakamori, Mitsuyoshi Ueda, Toyohiro Hirai and Young Hak Kim
    Mol Cancer Res January 1 2019 17 (1) 212-224; DOI:10.1158/1541-7786.MCR-18-0325

  • Signal Transduction
    The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer
    Sonia Manca, Cole P. Frisbie, Chad A. LaGrange, Carol A. Casey, Jean-Jack M. Riethoven and Armen Petrosyan
    Mol Cancer Res January 1 2019 17 (1) 225-237; DOI:10.1158/1541-7786.MCR-18-0577

  • Signal Transduction
    SOX9/FXYD3/Src Axis Is Critical for ER+ Breast Cancer Stem Cell Function
    Yue Xue, Lihua Lai, Wenwen Lian, Xintao Tu, Jiaojiao Zhou, Ping Dong, Dan Su, Xiaojia Wang, Xuetao Cao, Yiding Chen and Qingqing Wang
    Mol Cancer Res January 1 2019 17 (1) 238-249; DOI:10.1158/1541-7786.MCR-18-0610

  • Signal Transduction
    Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis
    He Shen, Nuo Yang, Alexander Truskinovsky, Yanmin Chen, Ashley L. Mussell, Norma J. Nowak, Lester Kobzik, Costa Frangou and Jianmin Zhang
    Mol Cancer Res January 1 2019 17 (1) 250-262; DOI:10.1158/1541-7786.MCR-18-0332

  • Signal Transduction
    Targeting the MIF/CXCR7/AKT Signaling Pathway in Castration-Resistant Prostate Cancer
    Shahrzad Rafiei, Bin Gui, Jiaxin Wu, X. Shirley Liu, Adam S. Kibel and Li Jia
    Mol Cancer Res January 1 2019 17 (1) 263-276; DOI:10.1158/1541-7786.MCR-18-0412

  • Signal Transduction
    TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions
    Brook S. Nepon-Sixt and Mark G. Alexandrow
    Mol Cancer Res January 1 2019 17 (1) 277-288; DOI:10.1158/1541-7786.MCR-18-0558

  • Signal Transduction
    Targeting of SGK1 by miR-576-3p Inhibits Lung Adenocarcinoma Migration and Invasion
    Evan J. Greenawalt, Mick D. Edmonds, Neha Jain, Clare M. Adams, Ramkrishna Mitra and Christine M. Eischen
    Mol Cancer Res January 1 2019 17 (1) 289-298; DOI:10.1158/1541-7786.MCR-18-0364

  • Signal Transduction
    miR-122-5p Expression and Secretion in Melanoma Cells Is Amplified by the LPAR3 SH3–Binding Domain to Regulate Wnt1
    Charnel C. Byrnes, Wei Jia, Ali A. Alshamrani, Sudeepti S. Kuppa and Mandi M. Murph
    Mol Cancer Res January 1 2019 17 (1) 299-309; DOI:10.1158/1541-7786.MCR-18-0460

Tumor Microenvironment

  • Tumor Microenvironment
    A Novel Approach for Image-Guided 131I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery
    Christina Schug, Aayush Gupta, Sarah Urnauer, Katja Steiger, Phyllis Fung-Yi Cheung, Christian Neander, Konstantinos Savvatakis, Kathrin A. Schmohl, Marija Trajkovic-Arsic, Nathalie Schwenk, Markus Schwaiger, Peter J. Nelson, Jens T. Siveke and Christine Spitzweg
    Mol Cancer Res January 1 2019 17 (1) 310-320; DOI:10.1158/1541-7786.MCR-18-0185

  • Tumor Microenvironment | AuthorChoice
    The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells
    Daniella Bianchi-Frias, Mamatha Damodarasamy, Susana A. Hernandez, Rui M. Gil da Costa, Funda Vakar-Lopez, Ilsa M. Coleman, May J. Reed and Peter S. Nelson
    Mol Cancer Res January 1 2019 17 (1) 321-331; DOI:10.1158/1541-7786.MCR-18-0522

Acknowledgment to Reviewers

  • Acknowledgment to Reviewers
    Acknowledgment to Reviewers
    Mol Cancer Res January 1 2019 17 (1) 332-334; DOI:10.1158/1541-7786.MCR_17_1_reviewers

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Molecular Cancer Research: 17 (1)
January 2019
Volume 17, Issue 1
  • Table of Contents
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Issue Highlights

  • Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors
  • Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk
  • Targeting the MIF/CXCR7/AKT Signaling Pathway in Castration-Resistant Prostate Cancer
  • TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions

Jump to

  • Highlights
  • Perspective
  • Cell Cycle and Senescence
  • Cell Death and Survival
  • Chromatin, Epigenetics, and RNA Regulation
  • DNA Damage and Repair
  • Genomics
  • Metabolism
  • Oncogenes and Tumor Suppressors
  • Signal Transduction
  • Tumor Microenvironment
  • Acknowledgment to Reviewers
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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