Molecular Cancer Research: 17 (1)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Res January 1 2019 17 (1) 1-1;

Perspective

Perspective

Lung-Enriched Mutations in the p53 Tumor Suppressor: A Paradigm for Tissue-Specific Gain of Oncogenic Function

Julie A. Barta and Steven B. McMahon

Mol Cancer Res January 1 2019 17 (1) 3-9; DOI:10.1158/1541-7786.MCR-18-0357

Cell Cycle and Senescence

Cell Cycle and Senescence

Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression

Feifei Wang, Ling Wang, Laura A. Fisher, Chunling Li, Weidong Wang and Aimin Peng

Mol Cancer Res January 1 2019 17 (1) 10-19; DOI:10.1158/1541-7786.MCR-17-0670

Cell Death and Survival

Cell Death and Survival

Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion

Rui Wang, Rajat Bhattacharya, Xiangcang Ye, Fan Fan, Delphine R. Boulbes and Lee M. Ellis

Mol Cancer Res January 1 2019 17 (1) 20-29; DOI:10.1158/1541-7786.MCR-18-0341

Chromatin, Epigenetics, and RNA Regulation

Chromatin, Epigenetics, and RNA Regulation

Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression

Thomas J. Rogers, Jessica L. Christenson, Lisa I. Greene, Kathleen I. O'Neill, Michelle M. Williams, Michael A. Gordon, Travis Nemkov, Angelo D'Alessandro, Greg D. Degala, Jimin Shin, Aik-Choon Tan, Diana M. Cittelly, James R. Lambert and Jennifer K. Richer

Mol Cancer Res January 1 2019 17 (1) 30-41; DOI:10.1158/1541-7786.MCR-18-0246

DNA Damage and Repair

DNA Damage and Repair

Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition

Abid R. Mattoo, Alex Joun and J. Milburn Jessup

Mol Cancer Res January 1 2019 17 (1) 42-53; DOI:10.1158/1541-7786.MCR-18-0650
DNA Damage and Repair

Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk

Ambre Petitalot, Elodie Dardillac, Eric Jacquet, Naima Nhiri, Josée Guirouilh-Barbat, Patrick Julien, Isslam Bouazzaoui, Dorine Bonte, Jean Feunteun, Jeff A. Schnell, Philippe Lafitte, Jean-Christophe Aude, Catherine Noguès, Etienne Rouleau, Rosette Lidereau, Bernard S. Lopez, Sophie Zinn-Justin and Sandrine M. Caputo; on behalf of the UNICANCER Genetic Group BRCA network

Mol Cancer Res January 1 2019 17 (1) 54-69; DOI:10.1158/1541-7786.MCR-17-0357

Genomics

Genomics | AuthorChoice

Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors

Isabel Romero-Calvo, Christopher R. Weber, Mohana Ray, Miguel Brown, Kori Kirby, Rajib K. Nandi, Tiha M. Long, Samantha M. Sparrow, Andrey Ugolkov, Wenan Qiang, Yilin Zhang, Tonya Brunetti, Hedy Kindler, Jeremy P. Segal, Andrey Rzhetsky, Andrew P. Mazar, Mary M. Buschmann, Ralph Weichselbaum, Kevin Roggin and Kevin P. White

Mol Cancer Res January 1 2019 17 (1) 70-83; DOI:10.1158/1541-7786.MCR-18-0531
Genomics

Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis

Hye-Young Nam, Darshan S. Chandrashekar, Anirban Kundu, Sandeep Shelar, Eun-Young Kho, Guru Sonpavde, Gurudatta Naik, Pooja Ghatalia, Carolina B. Livi, Sooryanarayana Varambally and Sunil Sudarshan

Mol Cancer Res January 1 2019 17 (1) 84-96; DOI:10.1158/1541-7786.MCR-17-0636
Genomics

Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers

Timothy R. Wilson, Akshata R. Udyavar, Ching-Wei Chang, Jill M. Spoerke, Junko Aimi, Heidi M. Savage, Anneleen Daemen, Joyce A. O'Shaughnessy, Richard Bourgon and Mark R. Lackner

Mol Cancer Res January 1 2019 17 (1) 97-108; DOI:10.1158/1541-7786.MCR-18-0619
Genomics

A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis

Yanding Zhao, Evelien Schaafsma, Ivan P. Gorlov, Eva Hernando, Nancy E. Thomas, Ronglai Shen, Mary Jo Turk, Marianne Berwick, Christopher I. Amos and Chao Cheng

Mol Cancer Res January 1 2019 17 (1) 109-119; DOI:10.1158/1541-7786.MCR-18-0173
Genomics

Establishment and Genetic Landscape of Precancer Cell Model Systems from the Head and Neck Mucosal Lining

D. Vicky de Boer, Arjen Brink, Marijke Buijze, Marijke Stigter-van Walsum, Keith D. Hunter, Bauke Ylstra, Elisabeth Bloemena, C. René Leemans and Ruud H. Brakenhoff

Mol Cancer Res January 1 2019 17 (1) 120-130; DOI:10.1158/1541-7786.MCR-18-0445

Metabolism

Metabolism

A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma

Lisa I. Greene, Tullia C. Bruno, Jessica L. Christenson, Angelo D'Alessandro, Rachel Culp-Hill, Kathleen Torkko, Virginia F. Borges, Jill E. Slansky and Jennifer K. Richer

Mol Cancer Res January 1 2019 17 (1) 131-139; DOI:10.1158/1541-7786.MCR-18-0362
Metabolism

De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer

Naser Jafari, James Drury, Andrew J. Morris, Fredrick O. Onono, Payton D. Stevens, Tianyan Gao, Jinpeng Liu, Chi Wang, Eun Y. Lee, Heidi L. Weiss, B. Mark Evers and Yekaterina Y. Zaytseva

Mol Cancer Res January 1 2019 17 (1) 140-152; DOI:10.1158/1541-7786.MCR-18-0199

Oncogenes and Tumor Suppressors

Oncogenes and Tumor Suppressors

p53–Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT

Yang Yang-Hartwich, Roslyn Tedja, Cai M. Roberts, Jamie Goodner-Bingham, Carlos Cardenas, Marta Gurea, Natalia J. Sumi, Ayesha B. Alvero, Carlotta A. Glackin and Gil Mor

Mol Cancer Res January 1 2019 17 (1) 153-164; DOI:10.1158/1541-7786.MCR-18-0238
Oncogenes and Tumor Suppressors

Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium–specific Deletion of Klf4

Vincent W. Yang, Yang Liu, Julie Kim, Kenneth R. Shroyer and Agnieszka B. Bialkowska

Mol Cancer Res January 1 2019 17 (1) 165-176; DOI:10.1158/1541-7786.MCR-18-0399
Oncogenes and Tumor Suppressors

Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing

Maria Alexiadis, Simone M. Rowley, Simon Chu, Dilys T.H. Leung, Colin J.R. Stewart, Kaushalya C. Amarasinghe, Ian G. Campbell and Peter J. Fuller

Mol Cancer Res January 1 2019 17 (1) 177-185; DOI:10.1158/1541-7786.MCR-18-0359
Oncogenes and Tumor Suppressors

p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma

Yun Wei, Victor Maximov, Sorana A. Morrissy, Michael D. Taylor, David C. Pallas and Anna Marie Kenney

Mol Cancer Res January 1 2019 17 (1) 186-198; DOI:10.1158/1541-7786.MCR-18-0485
Oncogenes and Tumor Suppressors

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma

Grace P. Leung, Tianshu Feng, Frederic D. Sigoillot, Felipe C. Geyer, Matthew D. Shirley, David A. Ruddy, Daniel P. Rakiec, Alyson K. Freeman, Jeffrey A. Engelman, Mariela Jaskelioff and Darrin D. Stuart

Mol Cancer Res January 1 2019 17 (1) 199-211; DOI:10.1158/1541-7786.MCR-18-0327

Signal Transduction

Signal Transduction

Alectinib Resistance in ALK-Rearranged Lung Cancer by Dual Salvage Signaling in a Clinically Paired Resistance Model

Takahiro Tsuji, Hiroaki Ozasa, Wataru Aoki, Shunsuke Aburaya, Tomoko Funazo, Koh Furugaki, Yasushi Yoshimura, Hitomi Ajimizu, Ryoko Okutani, Yuto Yasuda, Takashi Nomizo, Kiyoshi Uemasu, Koichi Hasegawa, Hironori Yoshida, Yoshitaka Yagi, Hiroki Nagai, Yuichi Sakamori, Mitsuyoshi Ueda, Toyohiro Hirai and Young Hak Kim

Mol Cancer Res January 1 2019 17 (1) 212-224; DOI:10.1158/1541-7786.MCR-18-0325
Signal Transduction

The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer

Sonia Manca, Cole P. Frisbie, Chad A. LaGrange, Carol A. Casey, Jean-Jack M. Riethoven and Armen Petrosyan

Mol Cancer Res January 1 2019 17 (1) 225-237; DOI:10.1158/1541-7786.MCR-18-0577
Signal Transduction

SOX9/FXYD3/Src Axis Is Critical for ER⁺ Breast Cancer Stem Cell Function

Yue Xue, Lihua Lai, Wenwen Lian, Xintao Tu, Jiaojiao Zhou, Ping Dong, Dan Su, Xiaojia Wang, Xuetao Cao, Yiding Chen and Qingqing Wang

Mol Cancer Res January 1 2019 17 (1) 238-249; DOI:10.1158/1541-7786.MCR-18-0610
Signal Transduction

Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis

He Shen, Nuo Yang, Alexander Truskinovsky, Yanmin Chen, Ashley L. Mussell, Norma J. Nowak, Lester Kobzik, Costa Frangou and Jianmin Zhang

Mol Cancer Res January 1 2019 17 (1) 250-262; DOI:10.1158/1541-7786.MCR-18-0332
Signal Transduction

Targeting the MIF/CXCR7/AKT Signaling Pathway in Castration-Resistant Prostate Cancer

Shahrzad Rafiei, Bin Gui, Jiaxin Wu, X. Shirley Liu, Adam S. Kibel and Li Jia

Mol Cancer Res January 1 2019 17 (1) 263-276; DOI:10.1158/1541-7786.MCR-18-0412
Signal Transduction

TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions

Brook S. Nepon-Sixt and Mark G. Alexandrow

Mol Cancer Res January 1 2019 17 (1) 277-288; DOI:10.1158/1541-7786.MCR-18-0558
Signal Transduction

Targeting of SGK1 by miR-576-3p Inhibits Lung Adenocarcinoma Migration and Invasion

Evan J. Greenawalt, Mick D. Edmonds, Neha Jain, Clare M. Adams, Ramkrishna Mitra and Christine M. Eischen

Mol Cancer Res January 1 2019 17 (1) 289-298; DOI:10.1158/1541-7786.MCR-18-0364
Signal Transduction

miR-122-5p Expression and Secretion in Melanoma Cells Is Amplified by the LPAR3 SH3–Binding Domain to Regulate Wnt1

Charnel C. Byrnes, Wei Jia, Ali A. Alshamrani, Sudeepti S. Kuppa and Mandi M. Murph

Mol Cancer Res January 1 2019 17 (1) 299-309; DOI:10.1158/1541-7786.MCR-18-0460

Tumor Microenvironment

Tumor Microenvironment

A Novel Approach for Image-Guided ¹³¹I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery

Christina Schug, Aayush Gupta, Sarah Urnauer, Katja Steiger, Phyllis Fung-Yi Cheung, Christian Neander, Konstantinos Savvatakis, Kathrin A. Schmohl, Marija Trajkovic-Arsic, Nathalie Schwenk, Markus Schwaiger, Peter J. Nelson, Jens T. Siveke and Christine Spitzweg

Mol Cancer Res January 1 2019 17 (1) 310-320; DOI:10.1158/1541-7786.MCR-18-0185
Tumor Microenvironment | AuthorChoice

The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells

Daniella Bianchi-Frias, Mamatha Damodarasamy, Susana A. Hernandez, Rui M. Gil da Costa, Funda Vakar-Lopez, Ilsa M. Coleman, May J. Reed and Peter S. Nelson

Mol Cancer Res January 1 2019 17 (1) 321-331; DOI:10.1158/1541-7786.MCR-18-0522

Acknowledgment to Reviewers

Acknowledgment to Reviewers

Acknowledgment to Reviewers

Mol Cancer Res January 1 2019 17 (1) 332-334; DOI:10.1158/1541-7786.MCR_17_1_reviewers

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Table of Contents

Highlights

Perspective

Cell Cycle and Senescence

Cell Death and Survival

Chromatin, Epigenetics, and RNA Regulation

DNA Damage and Repair

Genomics

Metabolism

Oncogenes and Tumor Suppressors

Signal Transduction

Tumor Microenvironment

Acknowledgment to Reviewers

Issue Highlights

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