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Molecular Cancer Research
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Editor's Notes

Editor's Note: Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells

DOI: 10.1158/1541-7786.MCR-18-0819 Published September 2018
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The Molecular Cancer Research editors are publishing this note to alert readers to a concern about this article (1). An internal journal investigation determined that the same β-actin immunoblot was reused to represent loading controls for reprobed conditions in Fig. 4A and C. In addition, an institutional investigation determined that data in this article were improperly reused from a Clinical Cancer Research article (2). Specifically, the microscopy images representing the apoptotic effects of UA treatment (Fig. 6A, top and bottom) and bortezomib treatment (Fig. 6A, bottom) in this article (1) were reused from panels representing capsaicin treatment (Fig. 6A and B) and Velcade (bortezomib) treatment (Fig. 6B), respectively, in the Clinical Cancer Research article (2). Original research records related to these concerns were not available during the institutional investigation. Therefore, the institution was not able to determine the relation of the images to the experiments described.

  • ©2018 American Association for Cancer Research.

References

  1. 1.↵
    1. Pathak AK,
    2. Bhutani M,
    3. Nair AS,
    4. Ahn KS,
    5. Chakraborty A,
    6. Kadara H,
    7. et al.
    Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 2007;5:943–55.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Bhutani M,
    2. Pathak AK,
    3. Nair AS,
    4. Kunnumakkara AB,
    5. Guha S,
    6. Sethi G,
    7. et al.
    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clin Cancer Res 2007;13:3024–32.
    OpenUrlAbstract/FREE Full Text
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Molecular Cancer Research: 16 (9)
September 2018
Volume 16, Issue 9
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Editor's Note: Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells
Mol Cancer Res September 1 2018 (16) (9) 1442; DOI: 10.1158/1541-7786.MCR-18-0819

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Editor's Note: Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells
Mol Cancer Res September 1 2018 (16) (9) 1442; DOI: 10.1158/1541-7786.MCR-18-0819
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Molecular Cancer Research
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