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Molecular Cancer Research
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Oncogenes and Tumor Suppressors

AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development

Jun Won Park, Il Yong Kim, Ji Won Choi, Hee Jung Lim, Jae Hoon Shin, Yo Na Kim, Seo Hyun Lee, Yeri Son, Mira Sohn, Jong Kyu Woo, Joseph H. Jeong, Cheolju Lee, Yun Soo Bae and Je Kyung Seong
Jun Won Park
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
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Il Yong Kim
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
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Ji Won Choi
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
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Hee Jung Lim
2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
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Jae Hoon Shin
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
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Yo Na Kim
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
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Seo Hyun Lee
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
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Yeri Son
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
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Mira Sohn
3Department of Life Sciences, Ewha Womans University, Seoul, Korea.
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Jong Kyu Woo
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
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Joseph H. Jeong
2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
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Cheolju Lee
4Center for Theragnosis, Korea Institute of Science and Technology, Seoul, Korea.
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Yun Soo Bae
3Department of Life Sciences, Ewha Womans University, Seoul, Korea.
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Je Kyung Seong
1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
5Interdisciplinary Program for Bioinformatics, Program for Cancer Biology and BIO-MAX/N-Bio Institute, Seoul National University, Seoul, Korea.
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  • For correspondence: snumouse@snu.ac.kr
DOI: 10.1158/1541-7786.MCR-17-0726 Published August 2018
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Article Information

Volume 16, Issue 8, pp. 1287-1298

DOI 
https://doi.org/10.1158/1541-7786.MCR-17-0726
PubMed 
29724814

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received December 4, 2017
  • Revision received January 24, 2018
  • Accepted April 19, 2018
  • Published first May 3, 2018.

Article Versions

  • Previous version (May 3, 2018 - 06:39).
  • Previous version (June 6, 2018 - 06:31).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Jun Won Park1,2,
  2. Il Yong Kim1,2,
  3. Ji Won Choi1,
  4. Hee Jung Lim2,
  5. Jae Hoon Shin1,
  6. Yo Na Kim1,
  7. Seo Hyun Lee1,
  8. Yeri Son1,
  9. Mira Sohn3,
  10. Jong Kyu Woo1,2,
  11. Joseph H. Jeong2,
  12. Cheolju Lee4,
  13. Yun Soo Bae3, and
  14. Je Kyung Seong1,2,5,*
  1. 1Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
  2. 2Korea Mouse Phenotyping Center (KMPC), Seoul, Korea.
  3. 3Department of Life Sciences, Ewha Womans University, Seoul, Korea.
  4. 4Center for Theragnosis, Korea Institute of Science and Technology, Seoul, Korea.
  5. 5Interdisciplinary Program for Bioinformatics, Program for Cancer Biology and BIO-MAX/N-Bio Institute, Seoul National University, Seoul, Korea.
  1. ↵*Corresponding Author:
    Je Kyung Seong, College of Veterinary Medicine, Seoul National University, Sinrym-dong, Seoul 151-742, Republic of Korea (South). Phone: 82-2-885-8395; Fax: 82-2-885-8397; E-mail: snumouse{at}snu.ac.kr
  1. J.W. Park and I.Y. Kim contributed equally to this article.

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Molecular Cancer Research: 16 (8)
August 2018
Volume 16, Issue 8
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AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Jun Won Park, Il Yong Kim, Ji Won Choi, Hee Jung Lim, Jae Hoon Shin, Yo Na Kim, Seo Hyun Lee, Yeri Son, Mira Sohn, Jong Kyu Woo, Joseph H. Jeong, Cheolju Lee, Yun Soo Bae and Je Kyung Seong
Mol Cancer Res August 1 2018 (16) (8) 1287-1298; DOI: 10.1158/1541-7786.MCR-17-0726

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AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Jun Won Park, Il Yong Kim, Ji Won Choi, Hee Jung Lim, Jae Hoon Shin, Yo Na Kim, Seo Hyun Lee, Yeri Son, Mira Sohn, Jong Kyu Woo, Joseph H. Jeong, Cheolju Lee, Yun Soo Bae and Je Kyung Seong
Mol Cancer Res August 1 2018 (16) (8) 1287-1298; DOI: 10.1158/1541-7786.MCR-17-0726
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