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Molecular Cancer Research
Molecular Cancer Research
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About the Cover

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ABOUT THE COVER
In this issue, a study by Brückmann and colleagues (beginning on page 417) demonstrates a novel epigenetic perturbation specific to premalignant and malignant cells. They show that chromosome 1q12 pericentromeric satellite DNA is epigenetically reprogrammed into a polycomb state forming subnuclear domains called polycomb bodies. The cover image shows the chromatin-associated distribution of polycomb protein BMI1 in the gallbladder, as it occurs in non-malignant tissues. This shift in epigenetic regulation of 1q12 satellite DNA presented by the authors may be used as an early diagnostic marker or new therapeutic target.

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Molecular Cancer Research: 16 (3)
March 2018
Volume 16, Issue 3
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Issue Highlights

  • Establishment of the First Well-differentiated Human Pancreatic Neuroendocrine Tumor Model
  • Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells
  • Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients
  • BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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