Molecular Cancer Research: 16 (3)

Highlights

Highlights

Highlights of This Issue

Mol Cancer Res March 1 2018 16 (3) 359-359;

Cell Cycle and Senescence

Cell Cycle and Senescence

Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells

Priyank Patel, Vladislav Tsiperson, Susan R.S. Gottesman, Jonathan Somma and Stacy W. Blain

Mol Cancer Res March 1 2018 16 (3) 361-377; DOI:10.1158/1541-7786.MCR-17-0602

Cell Death and Survival

Cell Death and Survival

Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer

Peng Zhang, Hisato Kawakami, Weizhen Liu, Xiangyu Zeng, Klaus Strebhardt, Kaixiong Tao, Shengbing Huang and Frank A. Sinicrope

Mol Cancer Res March 1 2018 16 (3) 378-389; DOI:10.1158/1541-7786.MCR-17-0404

Chromatin, Epigenetics and RNA Regulation

Chromatin, Epigenetics and RNA Regulation

Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

Margarita González-Vallinas, Manuel Rodríguez-Paredes, Marco Albrecht, Carsten Sticht, Damian Stichel, Julian Gutekunst, Adriana Pitea, Steffen Sass, Francisco J. Sánchez-Rivera, Justo Lorenzo-Bermejo, Jennifer Schmitt, Carolina De La Torre, Arne Warth, Fabian J. Theis, Nikola S. Müller, Norbert Gretz, Thomas Muley, Michael Meister, Darjus F. Tschaharganeh, Peter Schirmacher, Franziska Matthäus and Kai Breuhahn

Mol Cancer Res March 1 2018 16 (3) 390-402; DOI:10.1158/1541-7786.MCR-17-0334
Chromatin, Epigenetics and RNA Regulation

Differential Regulation of LET-7 by LIN28B Isoform–Specific Functions

Rei Mizuno, Priya Chatterji, Sarah Andres, Kathryn Hamilton, Lauren Simon, Shawn W. Foley, Arjun Jeganathan, Brian D. Gregory, Blair Madison and Anil K. Rustgi

Mol Cancer Res March 1 2018 16 (3) 403-416; DOI:10.1158/1541-7786.MCR-17-0514
Chromatin, Epigenetics and RNA Regulation

Epigenetic Reprogramming of Pericentromeric Satellite DNA in Premalignant and Malignant Lesions

Nadine Heidi Brückmann, Christina Bøg Pedersen, Henrik Jørn Ditzel and Morten Frier Gjerstorff

Mol Cancer Res March 1 2018 16 (3) 417-427; DOI:10.1158/1541-7786.MCR-17-0477

DNA Damage and Repair

DNA Damage and Repair | AuthorChoice

Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia

Franz Josef Gassner, Maria Schubert, Stefan Rebhandl, Karina Spandl, Nadja Zaborsky, Kemal Catakovic, Stephanie Blaimer, Daniel Hebenstreit, Richard Greil and Roland Geisberger

Mol Cancer Res March 1 2018 16 (3) 428-438; DOI:10.1158/1541-7786.MCR-17-0373

Metabolism

Metabolism

BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism

Karina Vázquez-Arreguín, Jessica Maddox, Jinsuk Kang, Dongju Park, Reuben R. Cano, Rachel E. Factor, Thomas Ludwig and Dean Tantin

Mol Cancer Res March 1 2018 16 (3) 439-452; DOI:10.1158/1541-7786.MCR-17-0364
Metabolism | AuthorChoice

Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-¹³C] Lactate

Sui Seng Tee, Izabela Suster, Steven Truong, Sangmoo Jeong, Roozbeh Eskandari, Valentina DiGialleonardo, Julio A. Alvarez, Hannah N. Aldeborgh and Kayvan R. Keshari

Mol Cancer Res March 1 2018 16 (3) 453-460; DOI:10.1158/1541-7786.MCR-17-0458

Genomics

Genomics | AuthorChoice

Population-dependent Intron Retention and DNA Methylation in Breast Cancer

Dongwook Kim, Manu Shivakumar, Seonggyun Han, Michael S. Sinclair, Young-Ji Lee, Yonglan Zheng, Olufunmilayo I. Olopade, Dokyoon Kim and Younghee Lee

Mol Cancer Res March 1 2018 16 (3) 461-469; DOI:10.1158/1541-7786.MCR-17-0227
Genomics

Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome

Jonathan Bond, Christine Tran Quang, Guillaume Hypolite, Mohamed Belhocine, Aurélie Bergon, Gaëlle Cordonnier, Jacques Ghysdael, Elizabeth Macintyre, Nicolas Boissel, Salvatore Spicuglia and Vahid Asnafi

Mol Cancer Res March 1 2018 16 (3) 470-475; DOI:10.1158/1541-7786.MCR-17-0442
Genomics | AuthorChoice

Multi-omics Approach Reveals Distinct Differences in Left- and Right-Sided Colon Cancer

Wangxiong Hu, Yanmei Yang, Xiaofen Li, Minran Huang, Fei Xu, Weiting Ge, Suzhan Zhang and Shu Zheng

Mol Cancer Res March 1 2018 16 (3) 476-485; DOI:10.1158/1541-7786.MCR-17-0483

Oncogenes and Tumor Suppressors

Oncogenes and Tumor Suppressors

Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression

David A. Drew, Allen Mo, James J. Grady, Richard G. Stevens, Joel B. Levine, Bruce M. Brenner, Joseph C. Anderson, Faripour Forouhar, Michael J. O'Brien, Thomas J. Devers and Daniel W. Rosenberg

Mol Cancer Res March 1 2018 16 (3) 486-495; DOI:10.1158/1541-7786.MCR-17-0380
Oncogenes and Tumor Suppressors

Establishment of the First Well-differentiated Human Pancreatic Neuroendocrine Tumor Model

Daniel Benten, Yasmin Behrang, Ludmilla Unrau, Victoria Weissmann, Gerrit Wolters-Eisfeld, Susanne Burdak-Rothkamm, Felix R. Stahl, Martin Anlauf, Patricia Grabowski, Markus Möbs, Jan Dieckhoff, Bence Sipos, Martina Fahl, Corinna Eggers, Daniel Perez, Maximillian Bockhorn, Jakob R. Izbicki, Ansgar W. Lohse and Jörg Schrader

Mol Cancer Res March 1 2018 16 (3) 496-507; DOI:10.1158/1541-7786.MCR-17-0163
Oncogenes and Tumor Suppressors

Keap1 Inhibits Metastatic Properties of NSCLC Cells by Stabilizing Architectures of F-Actin and Focal Adhesions

Bo Wu, Shu Yang, Haimei Sun, Tingyi Sun, Fengqing Ji, Yurong Wang, Lie Xu and Deshan Zhou

Mol Cancer Res March 1 2018 16 (3) 508-516; DOI:10.1158/1541-7786.MCR-17-0544
Oncogenes and Tumor Suppressors

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

Ryan A. Denu, Maria Shabbir, Minakshi Nihal, Chandra K. Singh, B. Jack Longley, Mark E. Burkard and Nihal Ahmad

Mol Cancer Res March 1 2018 16 (3) 517-527; DOI:10.1158/1541-7786.MCR-17-0197

Signal Transduction

Signal Transduction

Nanoscale Tuning of VCAM-1 Determines VLA-4–Dependent Melanoma Cell Plasticity on RGD Motifs

Katharina Amschler, Eugen Kossmann, Luise Erpenbeck, Sebastian Kruss, Tillmann Schill, Margarete Schön, Sigrid M.C. Möckel, Joachim P. Spatz and Michael P. Schön

Mol Cancer Res March 1 2018 16 (3) 528-542; DOI:10.1158/1541-7786.MCR-17-0272
Signal Transduction

TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer

Nina T. Solberg, Jo Waaler, Kaja Lund, Line Mygland, Petter A. Olsen and Stefan Krauss

Mol Cancer Res March 1 2018 16 (3) 543-553; DOI:10.1158/1541-7786.MCR-17-0362
Signal Transduction

Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis

Shuhei Enjoji, Ryotaro Yabe, Shunya Tsuji, Kazuhiro Yoshimura, Hideyoshi Kawasaki, Masashi Sakurai, Yusuke Sakai, Hiroko Takenouchi, Shigefumi Yoshino, Shoichi Hazama, Hiroaki Nagano, Hiroko Oshima, Masanobu Oshima, Michael P. Vitek, Tetsuya Matsuura, Yoshitaka Hippo, Tatsuya Usui, Takashi Ohama and Koichi Sato

Mol Cancer Res March 1 2018 16 (3) 554-563; DOI:10.1158/1541-7786.MCR-17-0393

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Table of Contents

Highlights

Cell Cycle and Senescence

Cell Death and Survival

Chromatin, Epigenetics and RNA Regulation

DNA Damage and Repair

Metabolism

Genomics

Oncogenes and Tumor Suppressors

Signal Transduction

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