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Molecular Cancer Research
Molecular Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Res March 1 2018 16 (3) 359-359;

Cell Cycle and Senescence

  • Cell Cycle and Senescence
    Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells
    Priyank Patel, Vladislav Tsiperson, Susan R.S. Gottesman, Jonathan Somma and Stacy W. Blain
    Mol Cancer Res March 1 2018 16 (3) 361-377; DOI:10.1158/1541-7786.MCR-17-0602

Cell Death and Survival

  • Cell Death and Survival
    Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer
    Peng Zhang, Hisato Kawakami, Weizhen Liu, Xiangyu Zeng, Klaus Strebhardt, Kaixiong Tao, Shengbing Huang and Frank A. Sinicrope
    Mol Cancer Res March 1 2018 16 (3) 378-389; DOI:10.1158/1541-7786.MCR-17-0404

Chromatin, Epigenetics and RNA Regulation

  • Chromatin, Epigenetics and RNA Regulation
    Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients
    Margarita González-Vallinas, Manuel Rodríguez-Paredes, Marco Albrecht, Carsten Sticht, Damian Stichel, Julian Gutekunst, Adriana Pitea, Steffen Sass, Francisco J. Sánchez-Rivera, Justo Lorenzo-Bermejo, Jennifer Schmitt, Carolina De La Torre, Arne Warth, Fabian J. Theis, Nikola S. Müller, Norbert Gretz, Thomas Muley, Michael Meister, Darjus F. Tschaharganeh, Peter Schirmacher, Franziska Matthäus and Kai Breuhahn
    Mol Cancer Res March 1 2018 16 (3) 390-402; DOI:10.1158/1541-7786.MCR-17-0334

  • Chromatin, Epigenetics and RNA Regulation
    Differential Regulation of LET-7 by LIN28B Isoform–Specific Functions
    Rei Mizuno, Priya Chatterji, Sarah Andres, Kathryn Hamilton, Lauren Simon, Shawn W. Foley, Arjun Jeganathan, Brian D. Gregory, Blair Madison and Anil K. Rustgi
    Mol Cancer Res March 1 2018 16 (3) 403-416; DOI:10.1158/1541-7786.MCR-17-0514

  • Chromatin, Epigenetics and RNA Regulation
    Epigenetic Reprogramming of Pericentromeric Satellite DNA in Premalignant and Malignant Lesions
    Nadine Heidi Brückmann, Christina Bøg Pedersen, Henrik Jørn Ditzel and Morten Frier Gjerstorff
    Mol Cancer Res March 1 2018 16 (3) 417-427; DOI:10.1158/1541-7786.MCR-17-0477

DNA Damage and Repair

  • DNA Damage and Repair | AuthorChoice
    Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia
    Franz Josef Gassner, Maria Schubert, Stefan Rebhandl, Karina Spandl, Nadja Zaborsky, Kemal Catakovic, Stephanie Blaimer, Daniel Hebenstreit, Richard Greil and Roland Geisberger
    Mol Cancer Res March 1 2018 16 (3) 428-438; DOI:10.1158/1541-7786.MCR-17-0373

Metabolism

  • Metabolism
    BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism
    Karina Vázquez-Arreguín, Jessica Maddox, Jinsuk Kang, Dongju Park, Reuben R. Cano, Rachel E. Factor, Thomas Ludwig and Dean Tantin
    Mol Cancer Res March 1 2018 16 (3) 439-452; DOI:10.1158/1541-7786.MCR-17-0364

  • Metabolism | AuthorChoice
    Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate
    Sui Seng Tee, Izabela Suster, Steven Truong, Sangmoo Jeong, Roozbeh Eskandari, Valentina DiGialleonardo, Julio A. Alvarez, Hannah N. Aldeborgh and Kayvan R. Keshari
    Mol Cancer Res March 1 2018 16 (3) 453-460; DOI:10.1158/1541-7786.MCR-17-0458

Genomics

  • Genomics | AuthorChoice
    Population-dependent Intron Retention and DNA Methylation in Breast Cancer
    Dongwook Kim, Manu Shivakumar, Seonggyun Han, Michael S. Sinclair, Young-Ji Lee, Yonglan Zheng, Olufunmilayo I. Olopade, Dokyoon Kim and Younghee Lee
    Mol Cancer Res March 1 2018 16 (3) 461-469; DOI:10.1158/1541-7786.MCR-17-0227

  • Genomics
    Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome
    Jonathan Bond, Christine Tran Quang, Guillaume Hypolite, Mohamed Belhocine, Aurélie Bergon, Gaëlle Cordonnier, Jacques Ghysdael, Elizabeth Macintyre, Nicolas Boissel, Salvatore Spicuglia and Vahid Asnafi
    Mol Cancer Res March 1 2018 16 (3) 470-475; DOI:10.1158/1541-7786.MCR-17-0442

  • Genomics | AuthorChoice
    Multi-omics Approach Reveals Distinct Differences in Left- and Right-Sided Colon Cancer
    Wangxiong Hu, Yanmei Yang, Xiaofen Li, Minran Huang, Fei Xu, Weiting Ge, Suzhan Zhang and Shu Zheng
    Mol Cancer Res March 1 2018 16 (3) 476-485; DOI:10.1158/1541-7786.MCR-17-0483

Oncogenes and Tumor Suppressors

  • Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression
    Oncogenes and Tumor Suppressors
    Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression
    David A. Drew, Allen Mo, James J. Grady, Richard G. Stevens, Joel B. Levine, Bruce M. Brenner, Joseph C. Anderson, Faripour Forouhar, Michael J. O'Brien, Thomas J. Devers and Daniel W. Rosenberg
    Mol Cancer Res March 1 2018 16 (3) 486-495; DOI:10.1158/1541-7786.MCR-17-0380

  • Oncogenes and Tumor Suppressors
    Establishment of the First Well-differentiated Human Pancreatic Neuroendocrine Tumor Model
    Daniel Benten, Yasmin Behrang, Ludmilla Unrau, Victoria Weissmann, Gerrit Wolters-Eisfeld, Susanne Burdak-Rothkamm, Felix R. Stahl, Martin Anlauf, Patricia Grabowski, Markus Möbs, Jan Dieckhoff, Bence Sipos, Martina Fahl, Corinna Eggers, Daniel Perez, Maximillian Bockhorn, Jakob R. Izbicki, Ansgar W. Lohse and Jörg Schrader
    Mol Cancer Res March 1 2018 16 (3) 496-507; DOI:10.1158/1541-7786.MCR-17-0163

  • Oncogenes and Tumor Suppressors
    Keap1 Inhibits Metastatic Properties of NSCLC Cells by Stabilizing Architectures of F-Actin and Focal Adhesions
    Bo Wu, Shu Yang, Haimei Sun, Tingyi Sun, Fengqing Ji, Yurong Wang, Lie Xu and Deshan Zhou
    Mol Cancer Res March 1 2018 16 (3) 508-516; DOI:10.1158/1541-7786.MCR-17-0544

  • Oncogenes and Tumor Suppressors
    Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma
    Ryan A. Denu, Maria Shabbir, Minakshi Nihal, Chandra K. Singh, B. Jack Longley, Mark E. Burkard and Nihal Ahmad
    Mol Cancer Res March 1 2018 16 (3) 517-527; DOI:10.1158/1541-7786.MCR-17-0197

Signal Transduction

  • Signal Transduction
    Nanoscale Tuning of VCAM-1 Determines VLA-4–Dependent Melanoma Cell Plasticity on RGD Motifs
    Katharina Amschler, Eugen Kossmann, Luise Erpenbeck, Sebastian Kruss, Tillmann Schill, Margarete Schön, Sigrid M.C. Möckel, Joachim P. Spatz and Michael P. Schön
    Mol Cancer Res March 1 2018 16 (3) 528-542; DOI:10.1158/1541-7786.MCR-17-0272

  • Signal Transduction
    TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer
    Nina T. Solberg, Jo Waaler, Kaja Lund, Line Mygland, Petter A. Olsen and Stefan Krauss
    Mol Cancer Res March 1 2018 16 (3) 543-553; DOI:10.1158/1541-7786.MCR-17-0362

  • Signal Transduction
    Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis
    Shuhei Enjoji, Ryotaro Yabe, Shunya Tsuji, Kazuhiro Yoshimura, Hideyoshi Kawasaki, Masashi Sakurai, Yusuke Sakai, Hiroko Takenouchi, Shigefumi Yoshino, Shoichi Hazama, Hiroaki Nagano, Hiroko Oshima, Masanobu Oshima, Michael P. Vitek, Tetsuya Matsuura, Yoshitaka Hippo, Tatsuya Usui, Takashi Ohama and Koichi Sato
    Mol Cancer Res March 1 2018 16 (3) 554-563; DOI:10.1158/1541-7786.MCR-17-0393

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Molecular Cancer Research: 16 (3)
March 2018
Volume 16, Issue 3
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

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Issue Highlights

  • Establishment of the First Well-differentiated Human Pancreatic Neuroendocrine Tumor Model
  • Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells
  • Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients
  • BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism

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  • Highlights
  • Cell Cycle and Senescence
  • Cell Death and Survival
  • Chromatin, Epigenetics and RNA Regulation
  • DNA Damage and Repair
  • Metabolism
  • Genomics
  • Oncogenes and Tumor Suppressors
  • Signal Transduction
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  • 27HC Disrupts Lipid Raft IL6–JAK–STAT3 in Prostate Cancer
  • Mesenchymal/MAPK Signatures of TERT Promoter Mutants
  • Evolving Evolvability and the Origins of Lethal Cancer
  • Vincristine Depletes Microtubule-Bound MYC in Mitosis
  • Combinatorial Lethality of OGT and CDK9 Inhibitors
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Molecular Cancer Research
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