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Table of Contents

Highlights

Highlights

Highlights of This Issue

Mol Cancer Res October 1 2018 16 (10) 1445-1445;

Rapid Impact

Rapid Impact

PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance

David Y.A. Dadey, Vaishali Kapoor, Arpine Khudanyan, Dinesh Thotala and Dennis E. Hallahan

Mol Cancer Res October 1 2018 16 (10) 1447-1453; DOI:10.1158/1541-7786.MCR-18-0224

Perspective

Perspective | AuthorChoice

Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition

Andrea C. Chaikovsky and Julien Sage

Mol Cancer Res October 1 2018 16 (10) 1454-1457; DOI:10.1158/1541-7786.MCR-18-0201

Cell Death and Survival

Cell Death and Survival | AuthorChoice

Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1

Yuhong Lu, Yanfeng Liu, Sebastian Oeck and Peter M. Glazer

Mol Cancer Res October 1 2018 16 (10) 1458-1469; DOI:10.1158/1541-7786.MCR-17-0637

Chromatin, Epigenetics and RNA Regulation

Chromatin, Epigenetics and RNA Regulation

LINC00152 Promotes Invasion through a 3′-Hairpin Structure and Associates with Prognosis in Glioblastoma

Brian J. Reon, Bruno Takao Real Karia, Manjari Kiran and Anindya Dutta

Mol Cancer Res October 1 2018 16 (10) 1470-1482; DOI:10.1158/1541-7786.MCR-18-0322

DNA Damage and Repair

DNA Damage and Repair

Thymidine Kinase 1 Loss Confers Trifluridine Resistance without Affecting 5-Fluorouracil Metabolism and Cytotoxicity

Keitaro Edahiro, Makoto Iimori, Takashi Kobunai, Tomomi Morikawa-Ichinose, Daisuke Miura, Yuki Kataoka, Shinichiro Niimi, Takeshi Wakasa, Hiroshi Saeki, Eiji Oki, Hiroyuki Kitao and Yoshihiko Maehara

Mol Cancer Res October 1 2018 16 (10) 1483-1490; DOI:10.1158/1541-7786.MCR-17-0686

Genomics

Genomics

Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

Anthony C. Wang, David T.W. Jones, Isaac Joshua Abecassis, Bonnie L. Cole, Sarah E.S. Leary, Christina M. Lockwood, Lukas Chavez, David Capper, Andrey Korshunov, Aria Fallah, Shelly Wang, Chibawanye Ene, James M. Olson, J. Russell Geyer, Eric C. Holland, Amy Lee, Richard G. Ellenbogen and Jeffrey G. Ojemann

Mol Cancer Res October 1 2018 16 (10) 1491-1498; DOI:10.1158/1541-7786.MCR-17-0507

Oncogenes and Tumor Suppressors

Oncogenes and Tumor Suppressors

BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number

Yuki Yoshino, Huicheng Qi, Hiroki Fujita, Matsuyuki Shirota, Shun Abe, Yuhei Komiyama, Kazuha Shindo, Masahiro Nakayama, Ayako Matsuzawa, Akihiro Kobayashi, Honami Ogoh, Toshio Watanabe, Chikashi Ishioka and Natsuko Chiba

Mol Cancer Res October 1 2018 16 (10) 1499-1511; DOI:10.1158/1541-7786.MCR-18-0269
Oncogenes and Tumor Suppressors

CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a

Xiaohui Zhao, Tian Xie, Ting Dai, Wenhui Zhao, Jing Li, Rui Xu, Chao Jiang, Peiqiong Li, Junyao Deng, Xiaobo Su and Ningfang Ma

Mol Cancer Res October 1 2018 16 (10) 1512-1522; DOI:10.1158/1541-7786.MCR-18-0157
Oncogenes and Tumor Suppressors

Daxx Functions Are p53-Independent In Vivo

Amanda R. Wasylishen, Jeannelyn S. Estrella, Vinod Pant, Gilda P. Chau and Guillermina Lozano

Mol Cancer Res October 1 2018 16 (10) 1523-1529; DOI:10.1158/1541-7786.MCR-18-0281
Oncogenes and Tumor Suppressors

Aromatase Acetylation Patterns and Altered Activity in Response to Sirtuin Inhibition

Deborah Molehin, Isabel Castro-Piedras, Monica Sharma, Souad R. Sennoune, Daphne Arena, Pulak R. Manna and Kevin Pruitt

Mol Cancer Res October 1 2018 16 (10) 1530-1542; DOI:10.1158/1541-7786.MCR-18-0047

Signal Transduction

Signal Transduction

S1P Stimulates Proliferation by Upregulating CTGF Expression through S1PR2-Mediated YAP Activation

Jung-Chien Cheng, Evan Y. Wang, Yuyin Yi, Avinash Thakur, Shu-Huei Tsai and Pamela A. Hoodless

Mol Cancer Res October 1 2018 16 (10) 1543-1555; DOI:10.1158/1541-7786.MCR-17-0681
Signal Transduction

YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity

Takaaki Sugihara, Nathan W. Werneburg, Matthew C. Hernandez, Lin Yang, Ayano Kabashima, Petra Hirsova, Lavanya Yohanathan, Carlos Sosa, Mark J. Truty, George Vasmatzis, Gregory J. Gores and Rory L. Smoot

Mol Cancer Res October 1 2018 16 (10) 1556-1567; DOI:10.1158/1541-7786.MCR-18-0158
Signal Transduction | AuthorChoice

BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis

Hans Petter Eikesdal, Lisa M. Becker, Yingqi Teng, Akane Kizu, Julienne L. Carstens, Keizo Kanasaki, Hikaru Sugimoto, Valerie S. LeBleu and Raghu Kalluri

Mol Cancer Res October 1 2018 16 (10) 1568-1578; DOI:10.1158/1541-7786.MCR-18-0120

Tumor Microenvironment

Tumor Microenvironment

Autocrine Fibronectin Inhibits Breast Cancer Metastasis

Aparna Shinde, Sarah Libring, Aktan Alpsoy, Ammara Abdullah, James A. Schaber, Luis Solorio and Michael K. Wendt

Mol Cancer Res October 1 2018 16 (10) 1579-1589; DOI:10.1158/1541-7786.MCR-18-0151
Tumor Microenvironment

Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma

Hyejin Jin, In-Hye Ham, Hye Jeong Oh, Cheong A Bae, Dakeun Lee, Young-Bae Kim, Sang-Yong Son, Yong-Joon Chwae, Sang-Uk Han, Rolf A. Brekken and Hoon Hur

Mol Cancer Res October 1 2018 16 (10) 1590-1600; DOI:10.1158/1541-7786.MCR-17-0710
Tumor Microenvironment

The Hypoxic Tumor Microenvironment Promotes Invadopodia Formation and Metastasis through LPA1 Receptor and EGFR Cooperation

Kelly Harper, Roxane R. Lavoie, Martine Charbonneau, Karine Brochu-Gaudreau and Claire M. Dubois

Mol Cancer Res October 1 2018 16 (10) 1601-1613; DOI:10.1158/1541-7786.MCR-17-0649