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Molecular Cancer Research
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Oncogenes and Tumor Suppressors

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance

Luca Malorni, Mario Giuliano, Ilenia Migliaccio, Tao Wang, Chad J. Creighton, Mathieu Lupien, Xiaoyong Fu, Susan G. Hilsenbeck, Nuala Healy, Carmine De Angelis, Abhijit Mazumdar, Meghana V. Trivedi, Suleiman Massarweh, Carolina Gutierrez, Sabino De Placido, Rinath Jeselsohn, Myles Brown, Powel H. Brown, C. Kent Osborne and Rachel Schiff
Luca Malorni
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
3Sandro Pitigliani Medical Oncology Unit and Translational Research Unit, Oncology Department, Hospital of Prato, Prato, Italy.
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  • For correspondence: rschiff@bcm.edu lmalorni@uslcentro.toscana.it
Mario Giuliano
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
4Department of Clinical Medicine and Surgery, Oncology Division, University of Naples Federico II, Naples, Italy.
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Ilenia Migliaccio
3Sandro Pitigliani Medical Oncology Unit and Translational Research Unit, Oncology Department, Hospital of Prato, Prato, Italy.
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Tao Wang
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
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Chad J. Creighton
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
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Mathieu Lupien
5Ontario Cancer Institute, Princess Margaret Cancer Center-University Health Network, Ontario Institute for Cancer Research and the Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
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Xiaoyong Fu
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
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Susan G. Hilsenbeck
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
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Nuala Healy
6Department of Radiology, St. James's Hospital, Dublin, Ireland.
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Carmine De Angelis
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
4Department of Clinical Medicine and Surgery, Oncology Division, University of Naples Federico II, Naples, Italy.
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Abhijit Mazumdar
7Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Meghana V. Trivedi
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
8Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas.
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Suleiman Massarweh
9Department of Medicine and Stanford Cancer Institute, Stanford University, Stanford, California.
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Carolina Gutierrez
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
10Department of Pathology, Baylor College of Medicine, Houston, Texas.
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Sabino De Placido
4Department of Clinical Medicine and Surgery, Oncology Division, University of Naples Federico II, Naples, Italy.
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Rinath Jeselsohn
11Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
12Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Myles Brown
11Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
12Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Powel H. Brown
7Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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C. Kent Osborne
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
13Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
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Rachel Schiff
1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
2Department of Medicine, Baylor College of Medicine, Houston, Texas.
13Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
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  • For correspondence: rschiff@bcm.edu lmalorni@uslcentro.toscana.it
DOI: 10.1158/1541-7786.MCR-15-0423 Published May 2016
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Article Information

Volume 14, Issue 5, pp. 470-481

DOI 
https://doi.org/10.1158/1541-7786.MCR-15-0423
PubMed 
26965145

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received February 12, 2016
  • Accepted February 20, 2016
  • Published first March 10, 2016.

Article Versions

  • Previous version (March 10, 2016 - 06:42).
  • Previous version (May 4, 2016 - 11:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Luca Malorni1,2,3,*,
  2. Mario Giuliano1,2,4,
  3. Ilenia Migliaccio3,
  4. Tao Wang1,
  5. Chad J. Creighton1,2,
  6. Mathieu Lupien5,
  7. Xiaoyong Fu1,2,
  8. Susan G. Hilsenbeck1,2,
  9. Nuala Healy6,
  10. Carmine De Angelis1,2,4,
  11. Abhijit Mazumdar7,
  12. Meghana V. Trivedi1,2,8,
  13. Suleiman Massarweh9,
  14. Carolina Gutierrez1,10,
  15. Sabino De Placido4,
  16. Rinath Jeselsohn11,12,
  17. Myles Brown11,12,
  18. Powel H. Brown7,
  19. C. Kent Osborne1,2,13, and
  20. Rachel Schiff1,2,13,*
  1. 1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
  2. 2Department of Medicine, Baylor College of Medicine, Houston, Texas.
  3. 3Sandro Pitigliani Medical Oncology Unit and Translational Research Unit, Oncology Department, Hospital of Prato, Prato, Italy.
  4. 4Department of Clinical Medicine and Surgery, Oncology Division, University of Naples Federico II, Naples, Italy.
  5. 5Ontario Cancer Institute, Princess Margaret Cancer Center-University Health Network, Ontario Institute for Cancer Research and the Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  6. 6Department of Radiology, St. James's Hospital, Dublin, Ireland.
  7. 7Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  8. 8Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas.
  9. 9Department of Medicine and Stanford Cancer Institute, Stanford University, Stanford, California.
  10. 10Department of Pathology, Baylor College of Medicine, Houston, Texas.
  11. 11Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
  12. 12Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.
  13. 13Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
  1. ↵*Corresponding Authors:
    Rachel Schiff, Baylor College of Medicine, 1 Baylor Plaza, Alkek Buld. N1230, Houston, TX 77030. Phone: 713-798-1676; Fax: 713-798-1659; E-mail: rschiff{at}bcm.edu; and Luca Malorni, Hospital of Prato, Sandro Pitigliani Medical Oncology Unit and Translational Research Unit, Via Suor Niccolina 20, Prato 59100, Italy. Phone: +39 0574 802523; Fax: +39 0574 802903; E-mail: lmalorni{at}uslcentro.toscana.it
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Molecular Cancer Research: 14 (5)
May 2016
Volume 14, Issue 5
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Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance
Luca Malorni, Mario Giuliano, Ilenia Migliaccio, Tao Wang, Chad J. Creighton, Mathieu Lupien, Xiaoyong Fu, Susan G. Hilsenbeck, Nuala Healy, Carmine De Angelis, Abhijit Mazumdar, Meghana V. Trivedi, Suleiman Massarweh, Carolina Gutierrez, Sabino De Placido, Rinath Jeselsohn, Myles Brown, Powel H. Brown, C. Kent Osborne and Rachel Schiff
Mol Cancer Res May 1 2016 (14) (5) 470-481; DOI: 10.1158/1541-7786.MCR-15-0423

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Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance
Luca Malorni, Mario Giuliano, Ilenia Migliaccio, Tao Wang, Chad J. Creighton, Mathieu Lupien, Xiaoyong Fu, Susan G. Hilsenbeck, Nuala Healy, Carmine De Angelis, Abhijit Mazumdar, Meghana V. Trivedi, Suleiman Massarweh, Carolina Gutierrez, Sabino De Placido, Rinath Jeselsohn, Myles Brown, Powel H. Brown, C. Kent Osborne and Rachel Schiff
Mol Cancer Res May 1 2016 (14) (5) 470-481; DOI: 10.1158/1541-7786.MCR-15-0423
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