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Molecular Cancer Research
Molecular Cancer Research
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About the Cover

Cover image

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Glioblastomas treated with the DNA alkylating agent temozolomide develop temozolomide-resistance driven by augmented homologous recombination. The cover image shows chromosomes from a temozolomide-resistant tumor. Tumor cells were cultured in BrdU, and treated with a DNA-damaging drug. Metaphase spreads were prepared from the treated cells, and chromosomes were stained with acridine orange (green). The chromosomes exhibit high numbers of sister chromatid exchanges which indicates high levels of homologous recombination repair of drug-induced DNA double-strand breaks. For more information, see the article by Gil del Alcazar and colleagues beginning on page 928.

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Molecular Cancer Research: 14 (10)
October 2016
Volume 14, Issue 10
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Issue Highlights

  • Amplification of TLK2 Induces Genomic Instability via Impairing the G2–M Checkpoint
  • MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma
  • ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma
  • Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer
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Molecular Cancer Research
eISSN: 1557-3125
ISSN: 1541-7786

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