IMPlicating Mesenchymal Imp1 in Colitis-Associated Cancer

Induction of Imp1 in fibroblasts and its action during colitis and cancer development. A, pathway for Imp1 in fibroblasts induction and how Imp1 controls COX2 (previous reports) and negatively controls HGF (Hamilton et al., this issue) are shown. Further relationships of these events with the development of colitis and CAC are outlined. B, consequences of Imp1 ablation are shown as a reduction in COX2 and PGE2 (blue arrows) and an increase in HGF (red arrows). Altogether, that results in increased colitis and enhanced CAC tumorigenesis.