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Table of Contents

Highlights

Highlights

Highlights of This Issue

Mol Cancer Res January 1 2015 13 (1) 1-1;

Review

Review

Therapeutic Targeting of Cellular Metabolism in Cells with Hyperactive mTORC1: A Paradigm Shift

Doug Medvetz, Carmen Priolo and Elizabeth P. Henske

Mol Cancer Res January 1 2015 13 (1) 3-8; DOI:10.1158/1541-7786.MCR-14-0343

Rapid Impact

Rapid Impact

CD44 Regulates Pancreatic Cancer Invasion through MT1-MMP

Wei Jiang, Yaqing Zhang, Kevin T. Kane, Meredith A. Collins, Diane M. Simeone, Marina Pasca di Magliano and Kevin Tri Nguyen

Mol Cancer Res January 1 2015 13 (1) 9-15; DOI:10.1158/1541-7786.MCR-14-0076

Cell Cycle and Senescence

Cell Cycle and Senescence

p53 Promotes Cell Survival due to the Reversibility of Its Cell-Cycle Checkpoints

Dana J. Lukin, Luis A. Carvajal, Wen-jun Liu, Lois Resnick-Silverman and James J. Manfredi

Mol Cancer Res January 1 2015 13 (1) 16-28; DOI:10.1158/1541-7786.MCR-14-0177
Cell Cycle and Senescence

CDK2 Transcriptional Repression Is an Essential Effector in p53-Dependent Cellular Senescence—Implications for Therapeutic Intervention

Hasan Zalzali, Bilal Nasr, Mohamad Harajly, Hussein Basma, Farah Ghamloush, Sandra Ghayad, Noël Ghanem, Gerard I Evan and Raya Saab

Mol Cancer Res January 1 2015 13 (1) 29-40; DOI:10.1158/1541-7786.MCR-14-0163
Cell Cycle and Senescence

SIRT1 Inactivation Evokes Antitumor Activities in NSCLC through the Tumor Suppressor p27

Lijia Zhu, Christine Y. Chiao, Katelyn G. Enzer, Alexander J. Stankiewicz, Douglas V. Faller and Yan Dai

Mol Cancer Res January 1 2015 13 (1) 41-49; DOI:10.1158/1541-7786.MCR-14-0239

Cell Death and Survival

Cell Death and Survival | AuthorChoice

High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting

Doug Medvetz, Yang Sun, Chenggang Li, Damir Khabibullin, Murugabaskar Balan, Andrey Parkhitko, Carmen Priolo, John M. Asara, Soumitro Pal, Jane Yu and Elizabeth P. Henske

Mol Cancer Res January 1 2015 13 (1) 50-62; DOI:10.1158/1541-7786.MCR-14-0440
Cell Death and Survival

Constitutively Active ErbB2 Regulates Cisplatin-Induced Cell Death in Breast Cancer Cells via Pro- and Antiapoptotic Mechanisms

Haraldur H. Sigurðsson, Christina W. Olesen, Rie Dybboe, Gitte Lauritzen and Stine F. Pedersen

Mol Cancer Res January 1 2015 13 (1) 63-77; DOI:10.1158/1541-7786.MCR-14-0011
Cell Death and Survival

Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2

Caitlin W. Brown, Alexander S. Brodsky and Richard N. Freiman

Mol Cancer Res January 1 2015 13 (1) 78-85; DOI:10.1158/1541-7786.MCR-14-0334
Cell Death and Survival | AuthorChoice

BIRO1, a Cell-Permeable BH3 Peptide, Promotes Mitochondrial Fragmentation and Death of Retinoblastoma Cells

Nathalie Allaman-Pillet, Anne Oberson and Daniel F. Schorderet

Mol Cancer Res January 1 2015 13 (1) 86-97; DOI:10.1158/1541-7786.MCR-14-0253

Chromatin, Gene, and RNA Regulation

Chromatin, Gene, and RNA Regulation

Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer

Adam G. Sowalsky, Zheng Xia, Liguo Wang, Hao Zhao, Shaoyong Chen, Glenn J. Bubley, Steven P. Balk and Wei Li

Mol Cancer Res January 1 2015 13 (1) 98-106; DOI:10.1158/1541-7786.MCR-14-0273
Chromatin, Gene, and RNA Regulation

Epigenetic Inactivation and Tumor-Suppressor Behavior of NGFR in Human Colorectal Cancer

Zuli Yang, Hao Chen, Lijun Huo, Zihuan Yang, Yang Bai, Xinjuan Fan, Beibei Ni, Lekun Fang, Jun Hu, Junsheng Peng, Lei Wang and Jianping Wang

Mol Cancer Res January 1 2015 13 (1) 107-119; DOI:10.1158/1541-7786.MCR-13-0247

DNA Damage and Repair

DNA Damage and Repair

A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Daniel L. Menezes, Jenny Holt, Yan Tang, Jiajia Feng, Paul Barsanti, Yue Pan, Majid Ghoddusi, Wei Zhang, George Thomas, Jocelyn Holash, Emma Lees and Lorena Taricani

Mol Cancer Res January 1 2015 13 (1) 120-129; DOI:10.1158/1541-7786.MCR-14-0240

Genomics

Genomics

RNA-seq Reveals Aurora Kinase–Driven mTOR Pathway Activation in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma

Sumanta K. Pal, Miaoling He, Tommy Tong, Huiqing Wu, Xueli Liu, Clayton Lau, Jin-Hui Wang, Charles Warden, Xiwei Wu, Sabina Signoretti, Toni K. Choueiri, Jose A. Karam and Jeremy O. Jones

Mol Cancer Res January 1 2015 13 (1) 130-137; DOI:10.1158/1541-7786.MCR-14-0352
Genomics

Alteration of Cell–Cell and Cell–Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3

Erica di Martino, Gavin Kelly, Jo-An Roulson and Margaret A. Knowles

Mol Cancer Res January 1 2015 13 (1) 138-148; DOI:10.1158/1541-7786.MCR-14-0022

Oncogenes and Tumor Suppressors

Oncogenes and Tumor Suppressors

Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential

Ginny L. Powers, Kimberly D.P. Hammer, Maribella Domenech, Katsiaryna Frantskevich, Rita L. Malinowski, Wade Bushman, David J. Beebe and Paul C. Marker

Mol Cancer Res January 1 2015 13 (1) 149-160; DOI:10.1158/1541-7786.MCR-14-0110
Oncogenes and Tumor Suppressors

Matrix Stiffening and β₁ Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer

Marta Puig, Roberto Lugo, Marta Gabasa, Alícia Giménez, Adriana Velásquez, Roland Galgoczy, Josep Ramírez, Abel Gómez-Caro, Óscar Busnadiego, Fernando Rodríguez-Pascual, Pere Gascón, Noemí Reguart and Jordi Alcaraz

Mol Cancer Res January 1 2015 13 (1) 161-173; DOI:10.1158/1541-7786.MCR-14-0155

Signal Transduction

Signal Transduction

Autotaxin and LPA₁ and LPA₅ Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

Sue-Chin Lee, Yuko Fujiwara, Jianxiong Liu, Junming Yue, Yoshibumi Shimizu, Derek D. Norman, Yaohong Wang, Ryoko Tsukahara, Erzsebet Szabo, Renukadevi Patil, Souvik Banerjee, Duane D. Miller, Louisa Balazs, Manik C. Ghosh, Christopher M. Waters, Tamas Oravecz and Gabor J. Tigyi

Mol Cancer Res January 1 2015 13 (1) 174-185; DOI:10.1158/1541-7786.MCR-14-0263
Signal Transduction

Loss of Keratinocytic RXRα Combined with Activated CDK4 or Oncogenic NRAS Generates UVB-Induced Melanomas via Loss of p53 and PTEN in the Tumor Microenvironment

Daniel J. Coleman, Sharmeen Chagani, Stephen Hyter, Anna M. Sherman, Christiane V. Löhr, Xiaobo Liang, Gitali Ganguli-Indra and Arup K. Indra

Mol Cancer Res January 1 2015 13 (1) 186-196; DOI:10.1158/1541-7786.MCR-14-0164
Signal Transduction

Annexin 2–CXCL12 Interactions Regulate Metastatic Cell Targeting and Growth in the Bone Marrow

Younghun Jung, Jingcheng Wang, Eunsohl Lee, Samantha McGee, Janice E. Berry, Kenji Yumoto, Jinlu Dai, Evan T. Keller, Yusuke Shiozawa and Russell S. Taichman

Mol Cancer Res January 1 2015 13 (1) 197-207; DOI:10.1158/1541-7786.MCR-14-0118