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Molecular Cancer Research
Molecular Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Mol Cancer Res January 1 2015 13 (1) 1-1;

Review

  • Review
    Therapeutic Targeting of Cellular Metabolism in Cells with Hyperactive mTORC1: A Paradigm Shift
    Doug Medvetz, Carmen Priolo and Elizabeth P. Henske
    Mol Cancer Res January 1 2015 13 (1) 3-8; DOI:10.1158/1541-7786.MCR-14-0343

Rapid Impact

  • CD44 Regulates Pancreatic Cancer Invasion through MT1-MMP
    Rapid Impact
    CD44 Regulates Pancreatic Cancer Invasion through MT1-MMP
    Wei Jiang, Yaqing Zhang, Kevin T. Kane, Meredith A. Collins, Diane M. Simeone, Marina Pasca di Magliano and Kevin Tri Nguyen
    Mol Cancer Res January 1 2015 13 (1) 9-15; DOI:10.1158/1541-7786.MCR-14-0076

Cell Cycle and Senescence

  • Cell Cycle and Senescence
    p53 Promotes Cell Survival due to the Reversibility of Its Cell-Cycle Checkpoints
    Dana J. Lukin, Luis A. Carvajal, Wen-jun Liu, Lois Resnick-Silverman and James J. Manfredi
    Mol Cancer Res January 1 2015 13 (1) 16-28; DOI:10.1158/1541-7786.MCR-14-0177

  • Cell Cycle and Senescence
    CDK2 Transcriptional Repression Is an Essential Effector in p53-Dependent Cellular Senescence—Implications for Therapeutic Intervention
    Hasan Zalzali, Bilal Nasr, Mohamad Harajly, Hussein Basma, Farah Ghamloush, Sandra Ghayad, Noël Ghanem, Gerard I Evan and Raya Saab
    Mol Cancer Res January 1 2015 13 (1) 29-40; DOI:10.1158/1541-7786.MCR-14-0163

  • Cell Cycle and Senescence
    SIRT1 Inactivation Evokes Antitumor Activities in NSCLC through the Tumor Suppressor p27
    Lijia Zhu, Christine Y. Chiao, Katelyn G. Enzer, Alexander J. Stankiewicz, Douglas V. Faller and Yan Dai
    Mol Cancer Res January 1 2015 13 (1) 41-49; DOI:10.1158/1541-7786.MCR-14-0239

Cell Death and Survival

  • Cell Death and Survival | AuthorChoice
    High-Throughput Drug Screen Identifies Chelerythrine as a Selective Inducer of Death in a TSC2-null Setting
    Doug Medvetz, Yang Sun, Chenggang Li, Damir Khabibullin, Murugabaskar Balan, Andrey Parkhitko, Carmen Priolo, John M. Asara, Soumitro Pal, Jane Yu and Elizabeth P. Henske
    Mol Cancer Res January 1 2015 13 (1) 50-62; DOI:10.1158/1541-7786.MCR-14-0440

  • Cell Death and Survival
    Constitutively Active ErbB2 Regulates Cisplatin-Induced Cell Death in Breast Cancer Cells via Pro- and Antiapoptotic Mechanisms
    Haraldur H. Sigurðsson, Christina W. Olesen, Rie Dybboe, Gitte Lauritzen and Stine F. Pedersen
    Mol Cancer Res January 1 2015 13 (1) 63-77; DOI:10.1158/1541-7786.MCR-14-0011

  • Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2
    Cell Death and Survival
    Notch3 Overexpression Promotes Anoikis Resistance in Epithelial Ovarian Cancer via Upregulation of COL4A2
    Caitlin W. Brown, Alexander S. Brodsky and Richard N. Freiman
    Mol Cancer Res January 1 2015 13 (1) 78-85; DOI:10.1158/1541-7786.MCR-14-0334

  • Cell Death and Survival | AuthorChoice
    BIRO1, a Cell-Permeable BH3 Peptide, Promotes Mitochondrial Fragmentation and Death of Retinoblastoma Cells
    Nathalie Allaman-Pillet, Anne Oberson and Daniel F. Schorderet
    Mol Cancer Res January 1 2015 13 (1) 86-97; DOI:10.1158/1541-7786.MCR-14-0253

Chromatin, Gene, and RNA Regulation

  • Chromatin, Gene, and RNA Regulation
    Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer
    Adam G. Sowalsky, Zheng Xia, Liguo Wang, Hao Zhao, Shaoyong Chen, Glenn J. Bubley, Steven P. Balk and Wei Li
    Mol Cancer Res January 1 2015 13 (1) 98-106; DOI:10.1158/1541-7786.MCR-14-0273

  • Chromatin, Gene, and RNA Regulation
    Epigenetic Inactivation and Tumor-Suppressor Behavior of NGFR in Human Colorectal Cancer
    Zuli Yang, Hao Chen, Lijun Huo, Zihuan Yang, Yang Bai, Xinjuan Fan, Beibei Ni, Lekun Fang, Jun Hu, Junsheng Peng, Lei Wang and Jianping Wang
    Mol Cancer Res January 1 2015 13 (1) 107-119; DOI:10.1158/1541-7786.MCR-13-0247

DNA Damage and Repair

  • DNA Damage and Repair
    A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function
    Daniel L. Menezes, Jenny Holt, Yan Tang, Jiajia Feng, Paul Barsanti, Yue Pan, Majid Ghoddusi, Wei Zhang, George Thomas, Jocelyn Holash, Emma Lees and Lorena Taricani
    Mol Cancer Res January 1 2015 13 (1) 120-129; DOI:10.1158/1541-7786.MCR-14-0240

Genomics

  • Genomics
    RNA-seq Reveals Aurora Kinase–Driven mTOR Pathway Activation in Patients with Sarcomatoid Metastatic Renal Cell Carcinoma
    Sumanta K. Pal, Miaoling He, Tommy Tong, Huiqing Wu, Xueli Liu, Clayton Lau, Jin-Hui Wang, Charles Warden, Xiwei Wu, Sabina Signoretti, Toni K. Choueiri, Jose A. Karam and Jeremy O. Jones
    Mol Cancer Res January 1 2015 13 (1) 130-137; DOI:10.1158/1541-7786.MCR-14-0352

  • Genomics
    Alteration of Cell–Cell and Cell–Matrix Adhesion in Urothelial Cells: An Oncogenic Mechanism for Mutant FGFR3
    Erica di Martino, Gavin Kelly, Jo-An Roulson and Margaret A. Knowles
    Mol Cancer Res January 1 2015 13 (1) 138-148; DOI:10.1158/1541-7786.MCR-14-0022

Oncogenes and Tumor Suppressors

  • Oncogenes and Tumor Suppressors
    Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential
    Ginny L. Powers, Kimberly D.P. Hammer, Maribella Domenech, Katsiaryna Frantskevich, Rita L. Malinowski, Wade Bushman, David J. Beebe and Paul C. Marker
    Mol Cancer Res January 1 2015 13 (1) 149-160; DOI:10.1158/1541-7786.MCR-14-0110

  • Oncogenes and Tumor Suppressors
    Matrix Stiffening and β1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer
    Marta Puig, Roberto Lugo, Marta Gabasa, Alícia Giménez, Adriana Velásquez, Roland Galgoczy, Josep Ramírez, Abel Gómez-Caro, Óscar Busnadiego, Fernando Rodríguez-Pascual, Pere Gascón, Noemí Reguart and Jordi Alcaraz
    Mol Cancer Res January 1 2015 13 (1) 161-173; DOI:10.1158/1541-7786.MCR-14-0155

Signal Transduction

  • Signal Transduction
    Autotaxin and LPA1 and LPA5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
    Sue-Chin Lee, Yuko Fujiwara, Jianxiong Liu, Junming Yue, Yoshibumi Shimizu, Derek D. Norman, Yaohong Wang, Ryoko Tsukahara, Erzsebet Szabo, Renukadevi Patil, Souvik Banerjee, Duane D. Miller, Louisa Balazs, Manik C. Ghosh, Christopher M. Waters, Tamas Oravecz and Gabor J. Tigyi
    Mol Cancer Res January 1 2015 13 (1) 174-185; DOI:10.1158/1541-7786.MCR-14-0263

  • Signal Transduction
    Loss of Keratinocytic RXRα Combined with Activated CDK4 or Oncogenic NRAS Generates UVB-Induced Melanomas via Loss of p53 and PTEN in the Tumor Microenvironment
    Daniel J. Coleman, Sharmeen Chagani, Stephen Hyter, Anna M. Sherman, Christiane V. Löhr, Xiaobo Liang, Gitali Ganguli-Indra and Arup K. Indra
    Mol Cancer Res January 1 2015 13 (1) 186-196; DOI:10.1158/1541-7786.MCR-14-0164

  • Signal Transduction
    Annexin 2–CXCL12 Interactions Regulate Metastatic Cell Targeting and Growth in the Bone Marrow
    Younghun Jung, Jingcheng Wang, Eunsohl Lee, Samantha McGee, Janice E. Berry, Kenji Yumoto, Jinlu Dai, Evan T. Keller, Yusuke Shiozawa and Russell S. Taichman
    Mol Cancer Res January 1 2015 13 (1) 197-207; DOI:10.1158/1541-7786.MCR-14-0118

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Molecular Cancer Research: 13 (1)
January 2015
Volume 13, Issue 1
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Molecular Cancer Research
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