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Volume 11, Issue 1, pp. 13-18
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History
- Received August 28, 2012
- Revision received October 3, 2012
- Accepted October 31, 2012
- Published first November 27, 2012.
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- Previous version (November 27, 2012 - 10:53).
- Previous version (January 4, 2013 - 13:26).
- You are viewing the most recent version of this article.
Copyright & Usage
©2012 American Association for Cancer Research.
Author Information
- Julie K. Horton and
- Samuel H. Wilson
- Authors' Affiliation: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina
- Corresponding Author:
Samuel H. Wilson, Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., MD F1-12, Research Triangle Park, NC 27709. Phone: 919-541-4701; Fax: 919-541-4724: E-mail: wilson5{at}niehs.nih.gov
January 2013
Volume 11, Issue 1
Volume 11, Issue 1
Predicting Enhanced Cell Killing through PARP Inhibition
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- Article
- Abstract
- Introduction
- Background on DNA Base Excision Repair
- Binding of PARP-1 to Intermediates of BER
- PARP Inhibition and Cellular Hypersensitivity to DNA Damage
- Influence of Pol β Expression on the Effect of PARP Inhibition
- Summary of 4-AN–Mediated Sensitization to Other Agents
- Concluding Remarks: Perspective on Predicting PARP Inhibitor Sensitization
- Disclosure of Potential Conflicts of Interest
- Authors' Contributions
- Grant Support
- Acknowledgments
- References
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