Table 1.

Incidence and sites of TRAMP-C2 cell dissemination and metastases

Injection siteAge groupNo. miceNo. mice metastasesMesenteryLiverSpleenKidneyEpid. fat padOthersa
i.p.Young104 (40)4 (40)0 (0)0 (0)3 (30)0 (0)1
i.p.Aged1815 (83)14 (78)3 (17)3 (17)7 (39)3 (17)6 (33)
i.v.Young81 (13)0 (0)0 (0)0 (0)0 (0)0 (0)1 (13)
i.v.Aged119 (82)6 (55)5 (45)4 (36)1 (9)0 (0)4 (36)
  • NOTE: Percentages of mice with tumor growth in distant organs are given in parentheses.

  • aPancreas, thymus, intestine, diaphragm.