Table 3.

Univariate and multivariate Cox proportional hazards analysis for 16p13.3 gain adjusting for standard clinicopathologic parameters

McGill cohortUnivariate analysisMultivariate analysis
VariableHR (95% CI)PaHR (95% CI)Pa
Preoperative PSAb1.07 (1.04–1.10)<0.00011.05 (1.02–1.08)<0.0001
GS (≥8 vs. ≤GS7)5.69 (3.01–10.76)<0.00013.06 (1.47–6.38)0.003
pT-stage (T3 vs. T2)3.46 (2.10–5.69)<0.00011.96 (1.10–3.48)0.02
16p13.3 status (gain vs. no gain)2.30 (1.40–3.78)0.0011.71 (1.01–2.89)0.04
Surgical margin (positive vs. negative)2.14 (1.30–3.51)0.0031.53 (0.88–2.64)0.12
  • Abbreviations: CI, confidence interval; HR, hazard ratio.

  • aWald test.

  • bAnalyzed as continuous variable.