Table 2.

Association of 16p13.3 gain with clinicopathologic features of aggressive prostate cancer

16p13.3 Status
Variables_McGill cohortTotal cases n (%)No gainGainP
16p13.3 Status267154 (58%)113 (42%)
Age (years) mean (±SD)61.8 (±5.8)61.0 (±6.12)60.7 (±5.64)0.68a
Preoperative PSA (mean/±SD)261b7.6 (±6.88)9.61 (±8.28)0.03a
GS267
 GS = 65949 (83%)10 (7%)<0.0001c
 GS = 718598 (53%)87 (47%)
 GS ≥ 8237 (30%)16 (70%)
Pathologic T-stage267
 pT2176118 (67%)58 (33%)<0.0001c
 pT3A7231 (43%)41 (57%)
 pT3B1905 (26%)14 (74%)
Surgical margins2670.009c
 Negative189119 (63%)70 (37%)
 Positive7835 (45%)43 (55%)
  • aUnpaired t test.

  • bValues not available for all the 267 cases that could be assessed by FISH (n noted for each variable).

  • cTwo-sided Fisher exact test.