Table 1.

Definitions of prostate cancer optimal foraging theory and dispersal

TermDefinitionEcologyProstate cancer biology
ResourceA depletable factor essential for survival, movement, or proliferationNuts, water, oxygenSugars, lipids, oxygen, etc.
PatchA depletable area of localized resourceOak treeRegion adjacent to a blood vessel
HabitatThe physical abiotic region in which an individual resides, segmented into resource patchesForestProstate tumor
SpeciesA group of individuals with a shared lineage and similar functional traitsSquirrels, hawksT-cells, prostate cells, fibroblasts
IndividualA species member that functions independently and consumes resourcesSquirrelCell
ForagingThe search for and consumption of resources in a habitat (mobile or stationary strategy)Squirrel forages for nutsCancer cell forages for oxygen
Stationary foragerAn individual that forages without moving to another patch regardless of patch depletionSpongeEpithelial cell
Mobile foragerAn individual that forages by moving among patchesSquirrel, hawkMesenchymal cell
PredatorAn individual that attacks and kills another individualHawkT-cell, M1 macrophage
Dispersal corridorAn inhabitable path through an inhospitable region linking two or more favorable habitatsRailroad tracks, riverBlood vessel, lymph vessel, nerve
AdaptationA fitness-enhancing phenotypic trait that is selected for by an external selective pressureWhite fur color of a snowshoe hareResistance to anoikis by a circulating tumor cell