Table 1.

Nucleolar Loss of Ku86 after DNA Damage

DNA DamageDoseNucleolar Exit of Ku86*
Cisplatin1-100 μg/mLYes
UVC300 J/m2Yes
γ-Irradiation10 GyYes
Doxorubicin5 μmol/LYes
Actinomycin D3 μg/mLYes
Hydroxyurea30 mmol/LYes
Mitomycin C50 μg/mLYes
  • *Nucleolar loss of Ku86 in >90% of the cells examined.