Table 1.

Alteration of DNA Damage Repair/Response Genes in HCT116R Cells

GeneHCT116-C1HCT116-C2HCT116-C3
PARP1−21.16−20.77−17.14
ATM−1.74−1.35−1.76
FANCF−1.72−1.49−1.60
FANCA2.251.571.32
PARP21.461.821.64
RAD11.561.871.83
MSH21.641.801.82
RAD512.022.232.43
BARD12.042.141.59
BRCA12.12.41.9
BLM2.362.432.02
CHK22.602.092.14
FANCG2.752.161.97
BRCA23.02.42.5

NOTE: DNA damage repair/response genes that are differentially regulated in all three resistant clones (>1.5-fold) were shown as fold change to that in parental HCT116 cells.