Research Articles: Therapeutics, Targets, and Development:

Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non–small cell lung carcinoma

Barbara A. Frederick, Barbara A. Helfrich, Christopher D. Coldren, Di Zheng, Dan Chan, Paul A. Bunn, Jr., and David Raben
Mol Cancer Ther 2007 6: 1683-1691Published Online First May 31, 2007. doi: 10.1158/1535-7163.MCT-07-0138 [Abstract] [Full Text] [PDF]  

The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth

Ronald P.C. Wong, Philip Ng, Shoukat Dedhar, and Gang Li
Mol Cancer Ther 2007 6: 1692-1700 doi: 10.1158/1535-7163.MCT-07-0134 [Abstract] [Full Text] [PDF]  

Detection of myeloma in skeleton of mice by whole-body optical fluorescence imaging

Babatunde O. Oyajobi, Steve Muñoz, Rami Kakonen, Paul J. Williams, Anjana Gupta, Christi L. Wideman, Beryl Story, Barry Grubbs, Allison Armstrong, William C. Dougall, I. Ross Garrett, and Gregory R. Mundy
Mol Cancer Ther 2007 6: 1701-1708Published Online First May 31, 2007. doi: 10.1158/1535-7163.MCT-07-0121 [Abstract] [Full Text] [PDF]  

Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice

Kaoru Kiguchi, Lynnsie Ruffino, Toru Kawamoto, Eugenia Franco, Shin-ichi Kurakata, Kosaku Fujiwara, Masaharu Hanai, Mohammad Rumi, and John DiGiovanni
Mol Cancer Ther 2007 6: 1709-1717 doi: 10.1158/1535-7163.MCT-07-0015 [Abstract] [Full Text] [PDF]  

5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells

Tanyel Kiziltepe, Teru Hideshima, Laurence Catley, Noopur Raje, Hiroshi Yasui, Norihiko Shiraishi, Yutaka Okawa, Hiroshi Ikeda, Sonia Vallet, Samantha Pozzi, Kenji Ishitsuka, Enrique M. Ocio, Dharminder Chauhan, and Kenneth C. Anderson
Mol Cancer Ther 2007 6: 1718-1727 doi: 10.1158/1535-7163.MCT-07-0010 [Abstract] [Full Text] [PDF]  

Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA

Jérôme Courtête, Annie-Paule Sibler, Gabrielle Zeder-Lutz, Deniz Dalkara, Mustapha Oulad-Abdelghani, Guy Zuber, and Etienne Weiss
Mol Cancer Ther 2007 6: 1728-1735 doi: 10.1158/1535-7163.MCT-06-0808 [Abstract] [Full Text] [PDF] Supplementary Data  

Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo

Michele T. Yip-Schneider, Huangbing Wu, Matthew Ralstin, Constantin Yiannoutsos, Peter A. Crooks, Sundar Neelakantan, Stephen Noble, Harikrishna Nakshatri, Christopher J. Sweeney, and C. Max Schmidt
Mol Cancer Ther 2007 6: 1736-1744Published Online First May 31, 2007. doi: 10.1158/1535-7163.MCT-06-0794 [Abstract] [Full Text] [PDF]  

The peroxisome proliferator-activated receptor- agonist troglitazone inhibits transforming growth factor-ß–mediated glioma cell migration and brain invasion

Roland Coras, Annett Hölsken, Sebastian Seufert, Jan Hauke, Ilker Y. Eyüpoglu, Martin Reichel, Christian Tränkle, Florian A. Siebzehnrübl, Rolf Buslei, Ingmar Blümcke, and Eric Hahnen
Mol Cancer Ther 2007 6: 1745-1754Published Online First May 31, 2007. doi: 10.1158/1535-7163.MCT-06-0763 [Abstract] [Full Text] [PDF]  

Characterization of the CCL21-mediated melanoma-specific immune responses and in situ melanoma eradication

Laura Novak, Olga Igoucheva, Stephanie Cho, and Vitali Alexeev
Mol Cancer Ther 2007 6: 1755-1764 doi: 10.1158/1535-7163.MCT-06-0709 [Abstract] [Full Text] [PDF]  

Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid)

Adi Zundelevich, Galit Elad-Sfadia, Ronit Haklai, and Yoel Kloog
Mol Cancer Ther 2007 6: 1765-1773Published Online First May 31, 2007. doi: 10.1158/1535-7163.MCT-06-0706 [Abstract] [Full Text] [PDF]  

Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism

Masayoshi Kobune, Hiroki Chiba, Junji Kato, Kazunori Kato, Kiminori Nakamura, Yutaka Kawano, Kohichi Takada, Rishu Takimoto, Tetsuji Takayama, Hirofumi Hamada, and Yoshiro Niitsu
Mol Cancer Ther 2007 6: 1774-1784 doi: 10.1158/1535-7163.MCT-06-0684 [Abstract] [Full Text] [PDF]  

Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice

Seungwon Kim, Yasemin D. Yazici, Gabriel Calzada, Zhuo-Ying Wang, Maher N. Younes, Samar A. Jasser, Adel K. El-Naggar, and Jeffrey N. Myers
Mol Cancer Ther 2007 6: 1785-1792 doi: 10.1158/1535-7163.MCT-06-0595 [Abstract] [Full Text] [PDF]  

Modifications enhance the apoptosis-inducing activity of FADD

Tomoki Takashina and Manabu Nakayama
Mol Cancer Ther 2007 6: 1793-1803 doi: 10.1158/1535-7163.MCT-06-0522 [Abstract] [Full Text] [PDF]  

Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes

Mikael Herlevsen, Gary Oxford, Charles R. Owens, Mark Conaway, and Dan Theodorescu
Mol Cancer Ther 2007 6: 1804-1813 doi: 10.1158/1535-7163.MCT-06-0372 [Abstract] [Full Text] [PDF]  

Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria

Tongzu Liu, Bethany Hannafon, Lance Gill, William Kelly, and Doris Benbrook
Mol Cancer Ther 2007 6: 1814-1822 doi: 10.1158/1535-7163.MCT-06-0279 [Abstract] [Full Text] [PDF]  

Gam1-associated alterations of drug responsiveness through activation of apoptosis

Fangting Wu, Susanna Chiocca, William T. Beck, and Yin-Yuan Mo
Mol Cancer Ther 2007 6: 1823-1830 doi: 10.1158/1535-7163.MCT-06-0771 [Abstract] [Full Text] [PDF]  

New transition state–based inhibitor for human ornithine decarboxylase inhibits growth of tumor cells

Fang Wu, Doris Grossenbacher, and Heinz Gehring
Mol Cancer Ther 2007 6: 1831-1839 doi: 10.1158/1535-7163.MCT-07-0045 [Abstract] [Full Text] [PDF]  

Orphan G protein–coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway

Ning Ke, Roshni Sundaram, Guohong Liu, John Chionis, Wufang Fan, Cheryl Rogers, Tarif Awad, Mirta Grifman, Dehua Yu, Flossie Wong-Staal, and Qi-Xiang Li
Mol Cancer Ther 2007 6: 1840-1850 doi: 10.1158/1535-7163.MCT-07-0066 [Abstract] [Full Text] [PDF] Supplementary Data  

A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia

Takayuki Ikezoe, Jing Yang, Chie Nishioka, Taizo Tasaka, Ayuko Taniguchi, Yoshio Kuwayama, Naoki Komatsu, Kentaro Bandobashi, Kazuto Togitani, H. Phillip Koeffler, and Hirokuni Taguchi
Mol Cancer Ther 2007 6: 1851-1857Published Online First May 31, 2007. doi: 10.1158/1535-7163.MCT-07-0067 [Abstract] [Full Text] [PDF]  

Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers

Sheryl A. Flanagan, Blaine W. Robinson, Christina M. Krokosky, and Donna S. Shewach
Mol Cancer Ther 2007 6: 1858-1868 doi: 10.1158/1535-7163.MCT-07-0068 [Abstract] [Full Text] [PDF]  

Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

Christina Westmose Yde, Mads Gyrd-Hansen, Anne E. Lykkesfeldt, Olaf-Georg Issinger, and Jan Stenvang
Mol Cancer Ther 2007 6: 1869-1876 doi: 10.1158/1535-7163.MCT-07-0072 [Abstract] [Full Text] [PDF]  

Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure

Robert W. Robey, Suneet Shukla, Kenneth Steadman, Tomasz Obrzut, Elizabeth M. Finley, Suresh V. Ambudkar, and Susan E. Bates
Mol Cancer Ther 2007 6: 1877-1885 doi: 10.1158/1535-7163.MCT-06-0811 [Abstract] [Full Text] [PDF]  

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

W. Wei-Lynn Wong, James W. Clendening, Anna Martirosyan, Paul C. Boutros, Christina Bros, Fereshteh Khosravi, Igor Jurisica, A. Keith Stewart, P. Leif Bergsagel, and Linda Z. Penn
Mol Cancer Ther 2007 6: 1886-1897 doi: 10.1158/1535-7163.MCT-06-0745 [Abstract] [Full Text] [PDF]  

Antitumor activity of CTFB, a novel anticancer agent, is associated with the down-regulation of nuclear factor-B expression and proteasome activation in head and neck squamous carcinoma cell lines

Sergej Skvortsov, Ira Skvortsova, Taras Stasyk, Natalia Schiefermeier, Andreas Neher, Andreas R. Gunkel, Guenther K. Bonn, Lukas A. Huber, Peter Lukas, Christopher M. Pleiman, and Heinz Zwierzina
Mol Cancer Ther 2007 6: 1898-1908 doi: 10.1158/1535-7163.MCT-06-0708 [Abstract] [Full Text] [PDF]  

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