Obituary:

Christoper J. Michejda

Jan M. Woynarowski
Mol Cancer Ther 2007 6: 1475-1476 doi: 10.1158/1535-7163.MCT-07-0270 [Full Text] [PDF]  

Spotlight on Clinical Response:

Studies in target-based treatment

Razelle Kurzrock
Mol Cancer Ther 2007 6: 1477Published Online First May 4, 2007. doi: 10.1158/1535-7163.MCT-07-0255 [Abstract] [Full Text] [PDF]  

p53 therapy in a patient with Li-Fraumeni syndrome

Neil Senzer, John Nemunaitis, Michael Nemunaitis, Jeffrey Lamont, Martin Gore, Hani Gabra, Rosalind Eeles, Nayanta Sodha, Frank J. Lynch, Louis A. Zumstein, Kerstin B. Menander, Robert E. Sobol, and Sunil Chada
Mol Cancer Ther 2007 6: 1478-1482Published Online First May 4, 2007. doi: 10.1158/1535-7163.MCT-07-0125 [Abstract] [Full Text] [PDF]  

Spotlight on Molecular Profiling:

MicroRNA expression profiles for the NCI-60 cancer cell panel

Paul E. Blower, Joseph S. Verducci, Shili Lin, Jin Zhou, Ji-Hyun Chung, Zunyan Dai, Chang-Gong Liu, William Reinhold, Philip L. Lorenzi, Eric P. Kaldjian, Carlo M. Croce, John N. Weinstein, and Wolfgang Sadee
Mol Cancer Ther 2007 6: 1483-1491Published Online First May 4, 2007. doi: 10.1158/1535-7163.MCT-07-0009 [Abstract] [Full Text] [PDF] Supplementary Data  

Research Articles: Therapeutics, Targets, and Development:

Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents

Yasunori Yoshimoto, Christina K. Augustine, Jin S. Yoo, Patricia A. Zipfel, M. Angelica Selim, Scott K. Pruitt, Henry S. Friedman, Francis Ali-Osman, and Douglas S. Tyler
Mol Cancer Ther 2007 6: 1492-1500Published Online First May 4, 2007. doi: 10.1158/1535-7163.MCT-06-0718 [Abstract] [Full Text] [PDF]  

Inhibition of topoisomerase II and G₂ cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials

Lei Guo, Xiaojun Liu, Kiyohiro Nishikawa, and William Plunkett
Mol Cancer Ther 2007 6: 1501-1508 doi: 10.1158/1535-7163.MCT-06-0780 [Abstract] [Full Text] [PDF]  

Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer

Antonio Jimeno, Gurulingappa Hallur, Audrey Chan, Xiangfeng Zhang, George Cusatis, Fonda Chan, Preeti Shah, Rongbing Chen, Ernest Hamel, Elizabeth Garrett-Mayer, Saeed Khan, and Manuel Hidalgo
Mol Cancer Ther 2007 6: 1509-1516Published Online First May 4, 2007. doi: 10.1158/1535-7163.MCT-06-0592 [Abstract] [Full Text] [PDF]  

Fasudil inhibits vascular endothelial growth factor–induced angiogenesis in vitro and in vivo

Limei Yin, Ken-ichirou Morishige, Toshifumi Takahashi, Kae Hashimoto, Seiji Ogata, Seiji Tsutsumi, Keiko Takata, Tsuyoshi Ohta, Jun Kawagoe, Kazuhiro Takahashi, and Hirohisa Kurachi
Mol Cancer Ther 2007 6: 1517-1525 doi: 10.1158/1535-7163.MCT-06-0689 [Abstract] [Full Text] [PDF]  

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor

Wilbert Zwart, Alexander Griekspoor, Mariska Rondaij, Desiree Verwoerd, Jacques Neefjes, and Rob Michalides
Mol Cancer Ther 2007 6: 1526-1533 doi: 10.1158/1535-7163.MCT-06-0750 [Abstract] [Full Text] [PDF]  

Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy

Lourdes A. Gomez, Alicia de las Pozas, Teresita Reiner, Kerry Burnstein, and Carlos Perez-Stable
Mol Cancer Ther 2007 6: 1534-1543 doi: 10.1158/1535-7163.MCT-06-0727 [Abstract] [Full Text] [PDF]  

Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells

Katherine M.A. Rogers, Michelle Thomas, Leeona Galligan, Timothy R. Wilson, Wendy L. Allen, Hidekazu Sakai, Patrick G. Johnston, and Daniel B. Longley
Mol Cancer Ther 2007 6: 1544-1551 doi: 10.1158/1535-7163.MCT-06-0673 [Abstract] [Full Text] [PDF]  

Enhanced tumor cell kill by combined treatment with a small-molecule antagonist of mouse double minute 2 and adenoviruses encoding p53

Harm C.A. Graat, Jan E. Carette, Frederik H.E. Schagen, Lyubomir T. Vassilev, Winald R. Gerritsen, Gertjan J.L. Kaspers, Paul I.J.M. Wuisman, and Victor W. van Beusechem
Mol Cancer Ther 2007 6: 1552-1561 doi: 10.1158/1535-7163.MCT-06-0631 [Abstract] [Full Text] [PDF]  

5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling

Rong-Ying Su, Yee Chao, Tsai-Yu Chen, Duen-Yi Huang, and Wan-Wan Lin
Mol Cancer Ther 2007 6: 1562-1571 doi: 10.1158/1535-7163.MCT-06-0800 [Abstract] [Full Text] [PDF]  

A bioactive withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression

Hui-Chiu Chang, Fang-Rong Chang, Yu-Chu Wang, Mei-Ren Pan, Wen-Chun Hung, and Yang-Chang Wu
Mol Cancer Ther 2007 6: 1572-1578 doi: 10.1158/1535-7163.MCT-06-0812 [Abstract] [Full Text] [PDF]  

ZD1839 induces p15^INK4b and causes G₁ arrest by inhibiting the mitogen-activated protein kinase/extracellular signal–regulated kinase pathway

Makoto Koyama, Youichirou Matsuzaki, Shingo Yogosawa, Toshiaki Hitomi, Mayumi Kawanaka, and Toshiyuki Sakai
Mol Cancer Ther 2007 6: 1579-1587 doi: 10.1158/1535-7163.MCT-06-0814 [Abstract] [Full Text] [PDF]  

Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator–activated receptor agonists in colon cancer cells

Sudhakar Chintharlapalli, Sabitha Papineni, Indira Jutooru, Alan McAlees, and Stephen Safe
Mol Cancer Ther 2007 6: 1588-1598 doi: 10.1158/1535-7163.MCT-07-0022 [Abstract] [Full Text] [PDF]  

Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak

Young-Ae Kim, Dong Xiao, Hui Xiao, Anna A. Powolny, Karen L. Lew, Megan L. Reilly, Yan Zeng, Zhou Wang, and Shivendra V. Singh
Mol Cancer Ther 2007 6: 1599-1609 doi: 10.1158/1535-7163.MCT-06-0754 [Abstract] [Full Text] [PDF]  

Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells

Gangxiong Huang, Lisa Mills, and Laura L. Worth
Mol Cancer Ther 2007 6: 1610-1619 doi: 10.1158/1535-7163.MCT-06-0580 [Abstract] [Full Text] [PDF]  

Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors

Raushan T. Kurmasheva, Franklin C. Harwood, and Peter J. Houghton
Mol Cancer Ther 2007 6: 1620-1628Published Online First May 4, 2007. doi: 10.1158/1535-7163.MCT-06-0646 [Abstract] [Full Text] [PDF]  

Delineation of molecular mechanisms of sensitivity to lapatinib in breast cancer cell lines using global gene expression profiles

Priti S. Hegde, David Rusnak, Melissa Bertiaux, Krystal Alligood, Jay Strum, Robert Gagnon, and Tona M. Gilmer
Mol Cancer Ther 2007 6: 1629-1640 doi: 10.1158/1535-7163.MCT-05-0399 [Abstract] [Full Text] [PDF]  

Shikonin circumvents cancer drug resistance by induction of a necroptotic death

Weidong Han, Ling Li, Shuang Qiu, Qinghua Lu, Qiangrong Pan, Ying Gu, Jianhong Luo, and Xun Hu
Mol Cancer Ther 2007 6: 1641-1649 doi: 10.1158/1535-7163.MCT-06-0511 [Abstract] [Full Text] [PDF] Supplementary Material  

Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation

Jonathan A.F. Hannay, Juehui Liu, Quan-Sheng Zhu, Svetlana V. Bolshakov, Lan Li, Peter W.T. Pisters, Alexander J.F. Lazar, Dihua Yu, Raphael E. Pollock, and Dina Lev
Mol Cancer Ther 2007 6: 1650-1660 doi: 10.1158/1535-7163.MCT-06-0636 [Abstract] [Full Text] [PDF]  

Transactivator of transcription–tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo

Liyue Zhang, Edi Levi, Pralay Majumder, Yingjie Yu, Amro Aboukameel, Jianhua Du, Hu Xu, Ramzi Mohammad, James S. Hatfield, Anil Wali, Volkan Adsay, Adhip P.N. Majumdar, and Arun K. Rishi
Mol Cancer Ther 2007 6: 1661-1672 doi: 10.1158/1535-7163.MCT-06-0653 [Abstract] [Full Text] [PDF]  

Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line

Anna Herman-Antosiewicz, Hui Xiao, Karen L. Lew, and Shivendra V. Singh
Mol Cancer Ther 2007 6: 1673-1681 doi: 10.1158/1535-7163.MCT-06-0807 [Abstract] [Full Text] [PDF]  

Correction:

Article on RAV12 antibody, oncosis, and antitumor activity

Mol Cancer Ther 2007 6: 1682 doi: 10.1158/1535-7163.MCT-06-5-COR [Full Text] [PDF]  

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