Detection of p63 by immunohistochemistry on paraffin-embedded normal prostate specimens. The image shows positive staining for p63 of the basal compartment of prostate epithelium, whereas the luminal/secretory cells are negative for this marker. An epithelial-restricted gene profile from adenocarcinoma-derived primary cells, highly enriched in luminal/secretory phenotype, has been derived and appears to contribute to predicting indolent versus aggressive clinical behavior of prostate cancer. For details, see the article by Nanni, et al. on page 79.

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