MCF-7 cells were transfected with the GFP-coupled minimal sequence of heregulin α, which were defined to be sufficient for nuclear import and subnuclear localization of heregulins in dot-like structures. Results demonstrate that nuclear dot formation by heregulin is independent of the EGF-like domain shown to be necessary for receptor binding and activation and may reflect unknown mechanisms of action of heregulin within the nucleus independent of the ErbB receptor system. For details, see the article by Breuleux, et al. on page 27.

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