Partially transformed crypts in the colon of ITFTag transgenic mice. Dysplastic crypts are apparent (center of figure) that contain normal cells lacking Tag expression (blue nuclei ) together with a population of spatially disorganized, Tag-expressing cells detected by immunohistochemistry (brown-staining nuclei ). This represents the earliest detectable step in tumorigenesis in this mouse model of colonic carcinoma. For details, see the article by Gum et al. on page 504

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