A high percentage of blood vessels in pancreatic tumors grown subcutaneously in wild-type mice show co-localization between a pan endothelial cell marker; MECA32 (green) and a marker of pericytes, smooth muscle α-actin (SMA, red). In contrast, there is a significant decrease in the percentage of blood vessels that demonstrate co-localization between MECA32 and SMA in pancreatic tumors grown in SPARC-null mice. For details, see article by Puolakkainen et al. on page 215.

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