Molecular Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
About the Cover

Cover Figure


On the Cover

Hypoxic cell populations (yellow/orange) in frozen sections from a human breast cancer xenograft overexpressing HER-2/neu (MDA-435/LCC6HER-2) visualized using immunofluorescence. Mice were exposed to 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3- pentafluoropropyl)-acetamide (EF5) before tumor harvest. EF5 forms adducts to cellular proteins in viable hypoxic cells that are subsequently detected with anti-EF5 antibody conjugated to CY3. Sections were then counterstained with DAPl (blue). Images were acquired separately for each fluorochrome and merged using Adobe Photoshop. For details, see the article by Dragowska et al. on page 606.

[Table of Contents]

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2005 by the American Association for Cancer Research.