Docking of genistein into the binding pocket of ERRa.Aromatic residue F414 from H12 stacks with F232 from H3 and F399 from H11 (upper panel). Docking of diethylstilbestrol into the binding pocket of ERa (lower panel). The pose of each ligand was chosen by CScore. Hydrogen bonds (yellow) are shown between the ligands and the protein, as well as the conserved water. Molecular surfaces of the ligand-binding cavity have been rendered with a translucent van der Waals surface (1.4Å probe) and are shown in green. For details, see the article by Suetsugi et al. on page 981.

[Table of Contents]