Glioblastoma multiforme (GBM) is one of the most common brain malignancies and has a very poor prognosis. Treatment options often include surgery, radiation, and chemotherapy. The use of the alkylating agent temozolomide has shown clinical benefit but resistance often ensues. Therefore, a better understanding of the molecular basis of this cancer is needed. The editors at Molecular Cancer Research have put together of collection of recent articles that delve into the oncogenic, metabolic, and signaling aspects of this cancer.
Prognostic relevance of tumor purity and TERT promoter mutations on MGMT promoter methylation in glioblastoma.
Heuling E Euskirchen P. Molecular Cancer Research 2017.
Astrocyte elevated gene-1 regulates β-catenin signaling to maintain glioma stem-like stemness and self-renewal.
Hu B Fisher PB. Molecular Cancer Research 2017.
The cytoskeletal adapter protein spinophilin regulates invadopodia dynamics and tumor cell invasion in glioblastoma.
Cheerathodi M McCarty JH. Molecular Cancer Research 2017.
Heparanase promotes glioma progression and is inversely correlated with patient survival.
Kundu S Forsberg-Nilsson K. Molecular Cancer Research 2017.
Increased expression of system xc− in glioblastoma confers an altered metabolic state and temozolomide resistance.
Polewski MD Aboody KS. Molecular Cancer Research 2017.
MNK inhibition disrupts mesenchymal glioma stem cells and prolongs survival in a mouse model of glioblastoma.
Bell JB Platanias LC. Molecular Cancer Research 2017.
Rapid conversion of mutant IDH1 from driver to passenger in a model of human gliomagenesis.
Johannessen TA Pieper RO. Molecular Cancer Research 2017.
Augmented HR repair mediates acquired temozolomide resistance in glioblastoma.
Gil Del Alcazar CR Burma S. Molecular Cancer Research 2017.
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