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Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation

Toshimitsu Yamaoka, Tohru Ohmori, Motoi Ohba, Satoru Arata, Yasunori Murata, Sojiro Kusumoto, Koichi Ando, Hiroo Ishida, Tsukasa Ohnishi and Yasutsuna Sasaki
Toshimitsu Yamaoka
Institute of Molecular Oncology, Showa University, Tokyo, Japan.
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  • For correspondence: yamaoka.t@med.showa-u.ac.jp
Tohru Ohmori
Institute of Molecular Oncology, Showa University, Tokyo, Japan.
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Motoi Ohba
Institute of Molecular Oncology, Showa University, Tokyo, Japan.
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Satoru Arata
Institute of Molecular Oncology, Showa University, Tokyo, Japan.Center for Biotechnology, Showa University, Tokyo, Japan.
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Yasunori Murata
Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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Sojiro Kusumoto
Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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Koichi Ando
Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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Hiroo Ishida
Division of Clinical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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Tsukasa Ohnishi
Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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Yasutsuna Sasaki
Division of Clinical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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DOI: 10.1158/1541-7786.MCR-16-0482
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Article Information

DOI 
https://doi.org/10.1158/1541-7786.MCR-16-0482
PubMed 
28289161

Published By 
American Association for Cancer Research
Print ISSN 
1541-7786
Online ISSN 
1557-3125
History 
  • Received December 22, 2016
  • Revision received December 21, 2016
  • Accepted March 7, 2017
  • Published first March 13, 2017.

Article Versions

  • Previous version (March 13, 2017 - 06:11).
  • You are currently viewing a Previous version of this article (May 18, 2017 - 06:38).
  • View the most recent version of this article
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Toshimitsu Yamaoka1,*,
  2. Tohru Ohmori1,
  3. Motoi Ohba1,
  4. Satoru Arata1,2,
  5. Yasunori Murata3,
  6. Sojiro Kusumoto3,
  7. Koichi Ando3,
  8. Hiroo Ishida4,
  9. Tsukasa Ohnishi3, and
  10. Yasutsuna Sasaki4
  1. 1Institute of Molecular Oncology, Showa University, Tokyo, Japan.
  2. 2Center for Biotechnology, Showa University, Tokyo, Japan.
  3. 3Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
  4. 4Division of Clinical Oncology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
  1. ↵*Corresponding Author:
    Toshimitsu Yamaoka, Institute of Molecular Oncology, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. Phone: 81-33784-8146; Fax: 81-33784-2299; E-mail: yamaoka.t{at}med.showa-u.ac.jp

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Published OnlineFirst May 18, 2017
doi: 10.1158/1541-7786.MCR-16-0482

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Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation
Toshimitsu Yamaoka, Tohru Ohmori, Motoi Ohba, Satoru Arata, Yasunori Murata, Sojiro Kusumoto, Koichi Ando, Hiroo Ishida, Tsukasa Ohnishi and Yasutsuna Sasaki
Mol Cancer Res May 18 2017 DOI: 10.1158/1541-7786.MCR-16-0482

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Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation
Toshimitsu Yamaoka, Tohru Ohmori, Motoi Ohba, Satoru Arata, Yasunori Murata, Sojiro Kusumoto, Koichi Ando, Hiroo Ishida, Tsukasa Ohnishi and Yasutsuna Sasaki
Mol Cancer Res May 18 2017 DOI: 10.1158/1541-7786.MCR-16-0482
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Molecular Cancer Research
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