MCR Must Read Collection
The MCR editors have identified a transformative “Must-Read” article from each section of the Journal that provides basic molecular insight and connectivity to cancer-associated processes. An author provided Visual Overview is also included that highlights the impact of these exciting findings.
BET bromodomain inhibitors enhance efficacy and disrupt resistance to AR antagonists in the treatment of prostate cancer.
Asangani IA Chinnaiyan AM. Molecular Cancer Research April 2016.
Understanding TERT promoter mutations: a common path to immortality.
Bell RJA CostelloJF. Molecular Cancer Research April 2016.
Cell Cycle and Senescence
AMPK causes cell cycle arrest in LKB1-deficient cells via activation of CAMKK2.
Fogarty S Hardie DG. Molecular Cancer Research August 2016.
Cell Death and Survival
Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells.
Shen F Fatatis A. Molecular Cancer Research June 2016.
Chromatin, Epigenetics, and RNA Regulation
GR and ER coactivation alters the expression of differentiation genes and associates with improved ER+ breast cancer outcome.
West DC Conzen SD. Molecular Cancer Research August 2016.
DNA Damage and Repair
Augmented HR repair mediates acquired temozolomide resistance in glioblastoma.
Gil del Alcazar CR…Burma S. Molecular Cancer Research October 2016.
A minimal DNA methylation signature in oral tongue squamous cell carcinoma links altered methylation with tumor attributes.
Krishnan NM Panda B. Molecular Cancer Research September 2016.
Gas1 inhibits metastatic and metabolic phenotypes in colorectal carcinoma
Li Q…Cai S. Molecular Cancer Research September 2016.
Oncogenes and Tumor Suppressors
Rapid conversion of mutant idh1 from driver to passenger in a model of human gliomagenesis.
Johannessen TCA…Pieper RO. Molecular Cancer Research October 2016.
Phosphoproteomics reveals mapk inhibitors enhance met- and egfr-driven akt signaling in kras-mutant lung cancer.
Kim JY …Haura EB. Molecular Cancer Research October 2016.
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