Molecular Cancer Research
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Molecular Cancer Research 5, 1-10, January 1, 2007. doi: 10.1158/1541-7786.MCR-06-0208
© 2007 American Association for Cancer Research
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Subject Review

Roles of Aurora Kinases in Mitosis and Tumorigenesis

Jingyan Fu, Minglei Bian, Qing Jiang and Chuanmao Zhang

The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education and the State Key Laboratory of Bio-membrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China

Requests for reprints: Chuanmao Zhang or Qing Jiang, College of Life Sciences, Peking University, Beijing 100871, China. Phone: 86-10-62757173; Fax: 86-10-62767246. E-mail: zhangcm{at}pku.edu.cn or jiangqing{at}pku.edu.cn

Abstract

Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. The activity of Aurora kinases is delicately regulated, mainly by phosphorylation and degradation. Deregulation of Aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. Both the expression level and the kinase activity of Aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. This review focuses on recent progress on the roles of Aurora kinases in mitosis and tumorigenesis. (Mol Cancer Res 2007;5(1):1–10)




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